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Targeted renal therapies through microbubbles and ultrasound☆
- Source :
- Advanced Drug Delivery Reviews. 62:1369-1377
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Microbubbles and ultrasound enhance the cellular uptake of drugs (including gene constructs) into the kidney. Microbubble induced modifications to the size selectivity of the filtration capacity of the kidney may enable drugs to enter previously inaccessible compartments of the kidney. So far, negative renal side-effects such as capillary bleeding have been reported only in rats, with no apparent damage in larger models such as pigs and rabbits. Although local delivery is accomplished by applying ultrasound only to the target area, efficient delivery using conventional microbubbles has depended on the combined injection of both drugs and microbubbles directly into the renal artery. Conjugation of antibodies to the shell of microbubbles allows for the specific accumulation of microbubbles in the target tissue after intravenous injection. This exciting approach opens new possibilities for both drug delivery and diagnostic ultrasound imaging in the kidney. (C) 2010 Elsevier B.V. All rights reserved.
- Subjects :
- Pathology
medicine.medical_specialty
Swine
Contrast Media
Molecular imaging
Pharmaceutical Science
Kidney
Article
Contrast agents
P-SELECTIN EXPRESSION
TUMOR ANGIOGENESIS
Drug Delivery Systems
medicine.artery
Ultrasound
medicine
Animals
Humans
Ultrasonics
Renal artery
INTERCELLULAR-ADHESION MOLECULE-1
IN-VIVO
Microbubbles
business.industry
Gene Transfer Techniques
ENHANCED ULTRASOUND
Kidney metabolism
Genetic Therapy
Bioeffects
MATRIX GENE-EXPRESSION
Rats
DIAGNOSTIC ULTRASOUND
Targeted microbubbles
medicine.anatomical_structure
Injections, Intravenous
Drug delivery
MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY
ENDOTHELIAL GROWTH-FACTOR
Kidney Diseases
Rabbits
AUTOIMMUNE ENCEPHALOMYELITIS EAE
business
Drug carrier
Subjects
Details
- ISSN :
- 0169409X
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews
- Accession number :
- edsair.doi.dedup.....dde664da584e8f8ce027d398322a99e5