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Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells
- Source :
- Nature Communications, Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4430. ⟨10.1038/s41467-019-12408⟩, Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019), Nature Communications, 2019, 10 (1), pp.4430. ⟨10.1038/s41467-019-12408⟩, Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-12408-x⟩, Nature Communications, 10(1):4430. Nature Publishing Group
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe neurological diseases. However the virus journey, from the bloodstream to tissues through a mature endothelium, remains unclear. Here, we show that ZIKV-infected monocytes represent suitable carriers for viral dissemination to the CNS using human primary monocytes, cerebral organoids derived from embryonic stem cells, organotypic mouse cerebellar slices, a xenotypic human-zebrafish model, and human fetus brain samples. We find that ZIKV-exposed monocytes exhibit higher expression of adhesion molecules, and higher abilities to attach onto the vessel wall and transmigrate across endothelia. This phenotype is associated to enhanced monocyte-mediated ZIKV dissemination to neural cells. Together, our data show that ZIKV manipulates the monocyte adhesive properties and enhances monocyte transmigration and viral dissemination to neural cells. Monocyte transmigration may represent an important mechanism required for viral tissue invasion and persistence that could be specifically targeted for therapeutic intervention.<br />Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.
- Subjects :
- Central Nervous System
0301 basic medicine
MESH: Neurons
General Physics and Astronomy
MESH: Organoids
MESH: Monocytes
Monocytes
Zika virus
0302 clinical medicine
MESH: Transendothelial and Transepithelial Migration
Cerebellum
MESH: Animals
lcsh:Science
MESH: Embryonic Stem Cells
ComputingMilieux_MISCELLANEOUS
Zebrafish
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Neurons
Multidisciplinary
Zika Virus Infection
Cell adhesion molecule
food and beverages
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie
Phenotype
3. Good health
Cell biology
Organoids
Mechanisms of disease
medicine.anatomical_structure
MESH: Cell Survival
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Female
Endothelium
Cell Survival
Science
MESH: Zika Virus
Biology
MESH: Endothelium
Article
General Biochemistry, Genetics and Molecular Biology
Virus
MESH: Cell Adhesion
03 medical and health sciences
Virology
medicine
Animals
Humans
MESH: Central Nervous System
Cellular microbiology
Cell adhesion
MESH: Zebrafish
Embryonic Stem Cells
MESH: Humans
Monocyte
fungi
Transendothelial and Transepithelial Migration
Zika Virus
General Chemistry
biology.organism_classification
Embryonic stem cell
MESH: Cerebellum
Disease Models, Animal
030104 developmental biology
lcsh:Q
MESH: Disease Models, Animal
Cell Adhesion Molecules
MESH: Female
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4430. ⟨10.1038/s41467-019-12408⟩, Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019), Nature Communications, 2019, 10 (1), pp.4430. ⟨10.1038/s41467-019-12408⟩, Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-12408-x⟩, Nature Communications, 10(1):4430. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....dde45bf7344e2f30ce082f9779330683