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The Correlation between Peripartum Cardiomyopathy and Autoantibodies against Cardiovascular Receptors
- Source :
- PLoS ONE, Vol 9, Iss 1, p e86770 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- BACKGROUND: Peripartum cardiomyopathy (PPCM) is characterized by left ventricular systolic dysfunction and heart failure. However, its pathogenesis is not clear. Our preliminary study revealed that autoantibodies against β1-adrenergic receptors (β1R-AABs) and M2-muscarinic receptors (M2R-AABs) participated in heart failure regardless of primary heart disease. Whether β1R-AABs and M2R-AABs participate in the pathogenesis of PPCM is still unknown. METHODS: Totally 37 diagnosed PPCM patients and 36 normal pregnant women were enrolled in this study. Clinical assessment and 2-dimensional echocardiographic studies as well as the measurement of β1R-AABs or M2R-AABs by enzyme linked immunosorbent assay (ELISA) were performed. RESULTS: The positive rates for β1R-AABs and M2R-AABs were 59.5% (22/37) and 45.9% (17/37) in PPCM patients, and 19.4% (7/36) (P
- Subjects :
- Peripartum cardiomyopathy
Heart disease
Cardiomyopathy
lcsh:Medicine
Cardiovascular
Biochemistry
Ventricular Function, Left
Diagnostic Radiology
Pathogenesis
Pregnancy
lcsh:Science
Multidisciplinary
Ejection fraction
Obstetrics and Gynecology
Echocardiography
Cardiology
Medicine
Female
Cardiomyopathies
Radiology
Research Article
Adult
Cardiomyopathy, Dilated
medicine.medical_specialty
Pregnancy Complications, Cardiovascular
Internal medicine
Cardiovascular Diseases in Women
Peripartum Period
medicine
Humans
Immunoassays
Biology
Autoantibodies
Heart Failure
Receptor, Muscarinic M2
business.industry
lcsh:R
Autoantibody
Proteins
medicine.disease
Pregnancy Complications
Case-Control Studies
Heart failure
Immunologic Techniques
Women's Health
Clinical Immunology
lcsh:Q
Receptors, Adrenergic, beta-1
business
Biomarkers
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....dde0f9849b2ac9821f4297ad7786451a