Back to Search
Start Over
The HA1 of cold-adapted influenza B vaccine is not altered during replication in human vaccinees
- Source :
- Virus research. 39(2-3)
- Publication Year :
- 1995
-
Abstract
- Influenza viruses recovered from 14 children 2-10 days after vaccination with an egg-grown, cold-adapted influenza B vaccine (B/AA/1/86) were analyzed. Hemagglutination-inhibition (HI) assays using monoclonal antibodies did not detect antigenic differences between the vaccine strain and the viruses recovered from the vaccinees. Furthermore, nucleotide sequence analysis of the HA1 region did not reveal any changes compared to the sequence of the vaccine strain. These findings indicate that influenza B vaccine hemagglutinin is genetically stable during replication in human vaccinees.
- Subjects :
- Cancer Research
medicine.drug_class
Hemagglutinin (influenza)
Hemagglutinin Glycoproteins, Influenza Virus
Biology
Monoclonal antibody
Virus Replication
H5N1 genetic structure
Antigenic drift
Microbiology
Cell Line
Dogs
Antigen
Virology
Reassortant Viruses
Influenza, Human
medicine
Animals
Humans
Vaccination
Hemagglutination Inhibition Tests
Influenza B virus
Infectious Diseases
Viral replication
Influenza Vaccines
biology.protein
RNA, Viral
Subjects
Details
- ISSN :
- 01681702
- Volume :
- 39
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Virus research
- Accession number :
- edsair.doi.dedup.....ddc2ec980b8a8629dac858404b2c88ff