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The role of long-range connections on the specificity of the macaque interareal cortical network
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (13), pp.5187-92. ⟨10.1073/pnas.1218972110⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- We investigated the influence of interareal distance on connectivity patterns in a database obtained from the injection of retrograde tracers in 29 areas distributed over six regions (occipital, temporal, parietal, frontal, prefrontal, and limbic). One-third of the 1,615 pathways projecting to the 29 target areas were reported only recently and deemed new-found projections (NFPs). NFPs are predominantly long-range, low-weight connections. A minimum dominating set analysis (a graph theoretic measure) shows that NFPs play a major role in globalizing input to small groups of areas. Randomization tests show that ( i ) NFPs make important contributions to the specificity of the connectivity profile of individual cortical areas, and ( ii ) NFPs share key properties with known connections at the same distance. We developed a similarity index, which shows that intraregion similarity is high, whereas the interregion similarity declines with distance. For area pairs, there is a steep decline with distance in the similarity and probability of being connected. Nevertheless, the present findings reveal an unexpected binary specificity despite the high density (66%) of the cortical graph. This specificity is made possible because connections are largely concentrated over short distances. These findings emphasize the importance of long-distance connections in the connectivity profile of an area. We demonstrate that long-distance connections are particularly prevalent for prefrontal areas, where they may play a prominent role in large-scale communication and information integration.
- Subjects :
- anatomy
Databases, Factual
Nerve net
Macaque
Brain mapping
03 medical and health sciences
0302 clinical medicine
Similarity (network science)
biology.animal
medicine
Range (statistics)
neocortex
Animals
030304 developmental biology
Cerebral Cortex
Brain Mapping
0303 health sciences
Multidisciplinary
Neocortex
biology
Biological Sciences
medicine.anatomical_structure
Geography
Cortical network
Macaca
Graph (abstract data type)
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Nerve Net
monkey
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (13), pp.5187-92. ⟨10.1073/pnas.1218972110⟩
- Accession number :
- edsair.doi.dedup.....ddb03b5acda08800e8187cd380666a0b