Back to Search
Start Over
Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease
- Source :
- International Journal of Rheumatology, Vol 2013 (2013), International Journal of Rheumatology
- Publication Year :
- 2013
- Publisher :
- Hindawi Publishing Corporation, 2013.
-
Abstract
- Immunoglobulin free light chains are produced in excess during normal antibody synthesis. Their evaluation is commonly used in case of a monoclonal gammopathy. In polyclonal hypergammaglobulinemia related to the Sjögren syndrome or systemic lupus, erythematosus serum free light chain levels are increased and could correlate with disease activity. We show here that theκ() andλ() free light chains and theκ : λratio () are increased in sixteen patients with IgG4-related disease when compared to healthy controls. The increase ofκandλfree light chains probably reflects the marked polyclonal B cell activation of the disease. We could not assess in this small cohort of patients a significative correlation of serum free light chain levels and disease activity or extension.
- Subjects :
- medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
biology
Article Subject
business.industry
Polyclonal hypergammaglobulinemia
Immunology
Immunoglobulin light chain
medicine.disease
Free Light Chain
Monoclonal gammopathy
Endocrinology
Rheumatology
Polyclonal antibodies
Internal medicine
Clinical Study
biology.protein
Medicine
IgG4-related disease
medicine.symptom
Antibody
lcsh:RC925-935
business
B-cell activation
Subjects
Details
- Language :
- English
- ISSN :
- 16879260
- Database :
- OpenAIRE
- Journal :
- International Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....ddae53a31fd8b45bf133b4568b998c16
- Full Text :
- https://doi.org/10.1155/2013/426759