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Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
- Source :
- Gut and Liver
- Publication Year :
- 2018
- Publisher :
- The Editorial Office of Gut and Liver, 2018.
-
Abstract
- Background/Aims: Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is an uncommon disease. Bone marrow involvement is reported even in patients with only a mucosal lesion. We evaluated the prevalence and risk factors of marrow involvement and its implications for diagnosis and treatment. Methods: In total, 132 patients who were diagnosed with gastric MALT lymphoma at the National Cancer Center in Korea between January 2001 and December 2016 were enrolled in the study. The patient data were collected and analyzed retrospectively. Results: Of the 132 patients, 47 (35.6%) were male, with a median age of 52 years (range, 17 to 81 years). The median follow-up duration was 48.8 months (range, 0.5 to 169.9 months). Helicobacter pylori infection was detected in 82 patients (62.1%). Most patients (80.3%) had stage IE1 according to the modified Ann Arbor staging system. Ninety-two patients underwent bone marrow evaluation, and four patients (4.3%) had marrow involvement. Of these patients, one presented with abdominal lymph node involvement, while the other three had stage IE1 disease if marrow involvement was disregarded. All three patients had no significant symptoms and were monitored after local treatment without evidence of disease aggravation. Conclusions: Bone marrow involvement was found in 4.3% of the patients with gastric MALT lymphoma. Bone marrow examination may be deferred because marrow involvement does not change the treatment options or outcome in gastric MALT lymphoma confined to the stomach wall. (Gut Liver 2018;12:278-287)
- Subjects :
- Male
Ann Arbor staging
Lymphoma
B-cell
Gastroenterology
0302 clinical medicine
Bone Marrow
Lymph node
Aged, 80 and over
medicine.diagnostic_test
biology
Stomach
Biopsy, Needle
Middle Aged
Prognosis
Anti-Bacterial Agents
Treatment Outcome
medicine.anatomical_structure
Lymphatic system
Bone marrow involvement
030220 oncology & carcinogenesis
Drug Therapy, Combination
Female
Original Article
030211 gastroenterology & hepatology
Adult
medicine.medical_specialty
Adolescent
Helicobacter Infections
Young Adult
03 medical and health sciences
Stomach Neoplasms
Internal medicine
medicine
Humans
Neoplasm Invasiveness
Aged
Retrospective Studies
Helicobacter pylori
Hepatology
business.industry
Endoscopy
Proton Pump Inhibitors
Lymphoma, B-Cell, Marginal Zone
medicine.disease
biology.organism_classification
Bone marrow examination
Gastric Mucosa
marginal zone
Bone marrow
Bone Marrow Neoplasms
business
Subjects
Details
- ISSN :
- 20051212 and 19762283
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Gut and Liver
- Accession number :
- edsair.doi.dedup.....ddad059165b35fa879e7e8d35bf291d5