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Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn
- Source :
- Neurogastroenterology and Motility. 18:292-299
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Oesophageal visceral hypersensitivity is thought to be important in generating symptoms in functional heartburn (FH). However, the neurophysiological mechanisms involved are poorly understood. The aim of this study was to compare the characteristics of oesophageal cortical evoked potentials (CEPs) induced by balloon distension and acid perfusion in FH and controls. We studied 21 FH patients and 12 healthy volunteers. Oesophageal mechanical stimulation was performed using the specially constructed mechanical pump. CEPs were recorded using the 10-20 international system of electroencephalogram recording. Oesophageal distention elicited recognizable, reproducible and muti-peak CEPs. CEP latencies for N1, P1 and N2 components were significantly shorter (P = 0.016, P = 0.003 and P = 0.031, respectively) in FH than in controls before perfusion. Acid perfusion significantly decreased the latencies of N1, P1 and N2 (P = 0.022, P = 0.007 and P = 0.041, respectively) and significantly increased the amplitude of P1-N2 components (P = 0.020) in FH patients, but not in controls. In conclusion, cortical evoked potential responses evoked by oesophageal distention and acid perfusion were greater in FH than in controls, suggesting that dysfunction of visceral neural pathways and/or alterations in cortical processing may produce and mediate oesophageal hypersensitivity in FH. These findings provide the evidence that central sensitization contributes to the development and maintenance of oesophageal hypersensitivity.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Physiology
Stimulation
Electroencephalography
Distension
Esophagus
Heartburn
Evoked Potentials, Somatosensory
Internal medicine
medicine
Humans
Evoked potential
Aged
Cerebral Cortex
medicine.diagnostic_test
Endocrine and Autonomic Systems
business.industry
Gastroenterology
Middle Aged
Dilatation
Perfusion
medicine.anatomical_structure
Hyperalgesia
Cerebral cortex
Cardiology
Female
Hydrochloric Acid
medicine.symptom
business
Subjects
Details
- ISSN :
- 13652982 and 13501925
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Neurogastroenterology and Motility
- Accession number :
- edsair.doi.dedup.....dda32f079b16036a4b5b9f5727c4ebb6