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Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury

Authors :
Csilla Viczenczova
K. Frimmel
Norbert Vrbjar
Rakesh C. Kukreja
Barbara Szeiffova Bacova
Ludmila Okruhlicova
Lucia Mézešová
Antigone Lazou
Tanya Ravingerova
Branislav Kura
M Ferko
Pavel Babal
Narcis Tribulova
Barbora Kalocayova
Miroslav Barancik
Pawan K. Singal
Jan Slezak
Source :
Canadian Journal of Physiology and Pharmacology. 95:1190-1203
Publication Year :
2017
Publisher :
Canadian Science Publishing, 2017.

Abstract

Irradiation of normal tissues leads to acute increase in reactive oxygen/nitrogen species that serve as intra- and inter-cellular signaling to alter cell and tissue function. In the case of chest irradiation, it can affect the heart, blood vessels, and lungs, with consequent tissue remodelation and adverse side effects and symptoms. This complex process is orchestrated by a large number of interacting molecular signals, including cytokines, chemokines, and growth factors. Inflammation, endothelial cell dysfunction, thrombogenesis, organ dysfunction, and ultimate failing of the heart occur as a pathological entity — “radiation-induced heart disease” (RIHD) that is major source of morbidity and mortality. The purpose of this review is to bring insights into the basic mechanisms of RIHD that may lead to the identification of targets for intervention in the radiotherapy side effect. Studies of authors also provide knowledge about how to select targeted drugs or biological molecules to modify the progression of radiation damage in the heart. New prospective studies are needed to validate that assessed factors and changes are useful as early markers of cardiac damage.

Details

ISSN :
12057541 and 00084212
Volume :
95
Database :
OpenAIRE
Journal :
Canadian Journal of Physiology and Pharmacology
Accession number :
edsair.doi.dedup.....dd953ee41a83cb9d8a5e8dd5a4648f12
Full Text :
https://doi.org/10.1139/cjpp-2017-0121