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Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury
- Source :
- Canadian Journal of Physiology and Pharmacology. 95:1190-1203
- Publication Year :
- 2017
- Publisher :
- Canadian Science Publishing, 2017.
-
Abstract
- Irradiation of normal tissues leads to acute increase in reactive oxygen/nitrogen species that serve as intra- and inter-cellular signaling to alter cell and tissue function. In the case of chest irradiation, it can affect the heart, blood vessels, and lungs, with consequent tissue remodelation and adverse side effects and symptoms. This complex process is orchestrated by a large number of interacting molecular signals, including cytokines, chemokines, and growth factors. Inflammation, endothelial cell dysfunction, thrombogenesis, organ dysfunction, and ultimate failing of the heart occur as a pathological entity — “radiation-induced heart disease” (RIHD) that is major source of morbidity and mortality. The purpose of this review is to bring insights into the basic mechanisms of RIHD that may lead to the identification of targets for intervention in the radiotherapy side effect. Studies of authors also provide knowledge about how to select targeted drugs or biological molecules to modify the progression of radiation damage in the heart. New prospective studies are needed to validate that assessed factors and changes are useful as early markers of cardiac damage.
- Subjects :
- 0301 basic medicine
Heart Injury
Heart Diseases
Side effect
Heart disease
Physiology
Ischemia
Apoptosis
Inflammation
Bioinformatics
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Animals
Humans
Medicine
Myocytes, Cardiac
Radiation Injuries
Pharmacology
business.industry
Mechanism (biology)
Organ dysfunction
Endothelial Cells
General Medicine
medicine.disease
Coronary Vessels
Oxidative Stress
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
Lipid Peroxidation
Inflammation Mediators
medicine.symptom
Reactive Oxygen Species
business
Biomarkers
Oxidative stress
DNA Damage
Signal Transduction
Subjects
Details
- ISSN :
- 12057541 and 00084212
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Physiology and Pharmacology
- Accession number :
- edsair.doi.dedup.....dd953ee41a83cb9d8a5e8dd5a4648f12
- Full Text :
- https://doi.org/10.1139/cjpp-2017-0121