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Diethylenetriamine/NONOate-doped alginate hydrogel with sustained nitric oxide release and minimal toxicity to accelerate healing of MRSA-infected wounds
- Source :
- Carbohydrate polymers. 270
- Publication Year :
- 2021
-
Abstract
- This study demonstrates the development of a nitric oxide (NO)-releasing hydrogel wound dressing and its efficacy at accelerating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound healing. A DETA/NONOate-doped alginate (Alg-DETA/NO) hydrogel was synthesized using alginate as a hydrogel-forming wound dressing material and diethylenetriamine/diazeniumdiolate (DETA/NONOate) as an NO donor. Alg-DETA/NO exhibited a prolonged NO release profile over a period of 4 days. The rheological properties of Alg-DETA/NO did not differ significantly from those of pure alginate. Importantly, Alg-DETA/NO showed potent antibacterial activity against MRSA, with minimal toxicity to mouse fibroblasts. The application of Alg-DETA/NO to MRSA-infected wounds in a mouse model showed a favorable wound healing with accelerated wound-size reduction and reduced skin bacterial infection. Additionally, histological examination revealed that Alg-DETA/NO reduced inflammation at the wound site and promoted re-epithelialization, angiogenesis, and collagen deposition. Thus, Alg-DETA/NO presented herein could serve as a safe and potent hydrogel dressing for the treatment of MRSA-infected wounds.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
Polymers and Plastics
Angiogenesis
Alginates
Inflammation
02 engineering and technology
Pharmacology
010402 general chemistry
medicine.disease_cause
Nitric Oxide
01 natural sciences
Nitric oxide
chemistry.chemical_compound
Mice
Re-Epithelialization
Materials Chemistry
medicine
Polyamines
Animals
Nitric Oxide Donors
Peroxidase
Mice, Inbred ICR
Wound Healing
integumentary system
Organic Chemistry
Hydrogels
021001 nanoscience & nanotechnology
NONOate
Bandages
0104 chemical sciences
Anti-Bacterial Agents
chemistry
Staphylococcus aureus
Toxicity
Collagen
medicine.symptom
0210 nano-technology
Wound healing
Antibacterial activity
Azo Compounds
Subjects
Details
- ISSN :
- 18791344
- Volume :
- 270
- Database :
- OpenAIRE
- Journal :
- Carbohydrate polymers
- Accession number :
- edsair.doi.dedup.....dd92fbf05f602a36361cd2b1c466fbdc