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Associated Variables of Myositis in Systemic Lupus Erythematosus: A Cross-Sectional Study
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2017
- Publisher :
- International Scientific Information, Inc., 2017.
-
Abstract
- BACKGROUND This study aimed to estimate the point prevalence of myositis and identify associated variables of myositis in systemic lupus erythematosus (SLE). MATERIAL AND METHODS Clinical date of patients hospitalized with lupus at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital were collected. Patients were defined as having myositis if they reported the presence of persistent invalidating muscular weakness combined with increased levels of creatine phosphokinase (CPK) and abnormal electromyography (EMG). RESULTS The study sample comprised 1701 lupus patients, of which 44 had myositis. Patients with SLE-associated myositis are more likely to have skin rash, alopecia, pericarditis, vasculitis, anti-Sm, anti-RNP, anti-dsDNA, thrombocytopenia, leukopenia, low C3, low C4, high erythrocyte sedimentation rate (ESR), high D-dimer, and active disease. Multivariate logistic regression found positive associations between leukopenia, alopecia, and active disease with myositis. Negative associations between myositis with the use of corticosteroids or immunosuppressive drugs were revealed in univariate and multivariate analysis. CONCLUSIONS The point prevalence of myositis was 2.6% in SLE patients. The significant association of alopecia, leukopenia, and active disease with myositis suggests that organ damage, hematological abnormality, and high disease activity promote the progression of myositis in lupus patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
03 medical and health sciences
Pericarditis
0302 clinical medicine
Risk Factors
Clinical Research
Internal medicine
Prevalence
medicine
Humans
Lupus Erythematosus, Systemic
skin and connective tissue diseases
Myositis
Demography
030203 arthritis & rheumatology
Lupus erythematosus
Systemic lupus erythematosus
Leukopenia
business.industry
General Medicine
Middle Aged
medicine.disease
Rash
Cross-Sectional Studies
Logistic Models
Multivariate Analysis
Female
medicine.symptom
business
Vasculitis
030217 neurology & neurosurgery
Anti-SSA/Ro autoantibodies
Subjects
Details
- ISSN :
- 16433750
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Medical Science Monitor
- Accession number :
- edsair.doi.dedup.....dd91058b775314fc48afe3462c9d93bb