Back to Search
Start Over
Role of total tumour load of sentinel lymph node on survival in early breast cancer patients
- Source :
- The Breast. 33:8-13
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Axillary staging (pN) is considered one of the most important prognostic factors in breast cancer patients. However, the Z0011 study data drastically reduced the number of surgical axillary dissections in a selected group of patients, limiting the prognostic information relating to axillary involvement to the sentinel lymph node (SLN). It is known that there is a relationship between SLN total tumour load (TTL) and axillary involvement. The objective of this study is to analyse the relationship between the TTL and outcomes in patients with early stage breast cancer. Patients and methods clinicopathological and follow-up data were collected from 950 patients with breast cancer between 2009 and 2010 on whom SLN analysis was conducted by molecular methods (One Step Nucleic Acid Amplification, Sysmex, Kobe, Japan). Results TTL (defined as the total number of CK19 mRNA copies in all positive SLN) correlates with disease free survival (HR, 1.08; p = 0.000004), with local recurrence disease free survival (HR = 1.07; p = 0.0014) and overall survival (HR: 1.08, p = 0.0032), clearly defining a low-risk group (TTL 4 CK19 mRNA copies/μL) versus a high-risk group (>2.5 × 10 4 CK 19 mRNA copies/μL). Conclusions SLN TTL permits the differentiation between two patient groups in terms of DFS and OS, independently of axillary staging (pN), age and tumour characteristics (size, grade, lymphovascular invasion). This new data confirms the clinical value of low axillary involvement and could partially replace the information that staging of the entire axilla provides in patients on whom no axillary lymph node dissection is performed.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Lymphovascular invasion
Sentinel lymph node
Breast Neoplasms
Kaplan-Meier Estimate
Disease-Free Survival
Cohort Studies
03 medical and health sciences
Breast cancer
0302 clinical medicine
Internal medicine
Humans
Medicine
Longitudinal Studies
RNA, Messenger
030212 general & internal medicine
Stage (cooking)
Aged
Neoplasm Staging
Early breast cancer
Keratin-19
Entire axilla
business.industry
Axillary Lymph Node Dissection
General Medicine
Total tumour load
Middle Aged
Prognosis
medicine.disease
Tumor Burden
030220 oncology & carcinogenesis
Axilla
Lymph Node Excision
Female
Surgery
Sentinel Lymph Node
business
Nucleic Acid Amplification Techniques
Axillary staging
Follow-Up Studies
Subjects
Details
- ISSN :
- 09609776
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- The Breast
- Accession number :
- edsair.doi.dedup.....dd879dbaa326b541d8311cf7d6577fcd