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Expression of cancer/testis (CT) antigens in squamous cell carcinoma of the head and neck: Evaluation as markers of squamous dysplasia
- Source :
- Pathology - Research and Practice. 209:721-726
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Cancer/testis (CT) antigens, normally only expressed in germ cells of adult testis, can be activated in malignancy as tumor-specific antigens. The potential value of CT antigens as biomarkers in the evaluation of mucosal squamous precursor lesions of the head and neck has not been investigated. The expression of 8 CT antigens (MAGE-A, GAGE, NY-ESO-1, CT7, CT10, SAGE1, CT45 and NXF2) in 76 cases of invasive head and neck squamous cell carcinoma (SCC) was evaluated immunohistochemically. 65 mucosal biopsies of squamous dysplasia and 55 squamous papillomas with dysplasia were analyzed for 6 CT antigens, using an antibody cocktail. Of invasive SCC, 66% (50/76) expressed at least one CT antigen, most commonly MAGE-A (47%). Among the biopsies, only 1 of 55 squamous papillomas was CT-positive, whereas 8 of 65 (12%) squamous dysplasia lesions were CT-positive. These 8 CT-positive biopsies were from 6 patients, 3 of which had concurrent or subsequent SCC. CT antigens are frequently expressed in head and neck SCC; however, there was no difference in the clinicopathological characteristics or behavior of CT-positive tumors compared to CT-negative tumors. The usefulness of CT antigens as positive predictors for SCC in squamous dysplasia biopsies remains to be determined by long-term follow-up in larger cohorts.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Biopsy
Malignancy
Pathology and Forensic Medicine
Antigen
Antigens, Neoplasm
Testis
Biomarkers, Tumor
medicine
Humans
Head and neck
biology
Squamous Cell Carcinoma of Head and Neck
business.industry
Cancer
Cell Biology
Middle Aged
medicine.disease
Immunohistochemistry
Head and neck squamous-cell carcinoma
stomatognathic diseases
Head and Neck Neoplasms
Dysplasia
Carcinoma, Squamous Cell
biology.protein
Female
Neoplasm Grading
Antibody
business
Subjects
Details
- ISSN :
- 03440338
- Volume :
- 209
- Database :
- OpenAIRE
- Journal :
- Pathology - Research and Practice
- Accession number :
- edsair.doi.dedup.....dd836e8d9d03b6b0c12803ea6c293c25