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Assessment of Interferon-Gamma Release Assay in Patients with Non-Tuberculous Mycobacteria Pulmonary Disease
- Source :
- Clinical laboratory. 65(10)
- Publication Year :
- 2019
-
Abstract
- Background Interferon-gamma release assay (T-SPOT.TB) has the theoretical possibility of discriminating TB from most non-tuberculous mycobacteria (NTM) infections, but there are limited reports on the use of T-SPOT.TB for diseases due to NTM in high TB burden country. The aim of the present study was to assess the utility of T-SPOT.TB in patients with NTM pulmonary disease. Methods Clinical parameters and laboratory characteristics of patients with NTM pulmonary disease between July 2011 and Jan 2017 were investigated retrospectively and comprehensively reviewed. Results A total of 127 patients with NTM pulmonary disease were retrospectively reviewed. Seven NTM species were isolated from 115 patients, and the most common species were M. intracellulare (48.7%, 56/115) and M. abscessus (34.8%, 40/115). NTM isolates were mainly prevalent in people aged 50 years or older (73.0%). The overall positive rate of T-SPOT.TB test was 29.6% (24/81). In patients infected with NTM sharing the RD1 region of Mycobacterium tuberculosis (M. TB), 50% (3/6) were positive in the T-SPOT.TB test, whereas 28.0% (21/75) was positive in the group with NTM not sharing the RD1 region of M. TB. No significant difference was detected in the positive rate of T-SPOT.TB between definite (28.3%, 15/53) and probable disease (32.1%, 9/28). Conclusions Our data indicated a relatively high positive rate of T-SPOT.TB test in patients infected with NTM not sharing the RD1 region of M. TB. Thus, T-SPOT.TB test displays a limited ability in differentiating TB infection from NTM disease in a high TB burden country.
- Subjects :
- Adult
Male
medicine.medical_specialty
Tuberculosis
Interferon gamma release assay
Mycobacterium Infections, Nontuberculous
Disease
Sensitivity and Specificity
General Biochemistry, Genetics and Molecular Biology
Mycobacterium tuberculosis
Diagnosis, Differential
Tuberculosis diagnosis
Internal medicine
Diabetes mellitus
medicine
Humans
In patient
Tuberculosis, Pulmonary
Aged
Retrospective Studies
Aged, 80 and over
biology
business.industry
Reproducibility of Results
Retrospective cohort study
Nontuberculous Mycobacteria
Middle Aged
bacterial infections and mycoses
biology.organism_classification
medicine.disease
Female
business
Interferon-gamma Release Tests
Subjects
Details
- ISSN :
- 14336510
- Volume :
- 65
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical laboratory
- Accession number :
- edsair.doi.dedup.....dd81396924d9e352d34b0260c3676e0d