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Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies
- Source :
- Cell. 158(3):481-491
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- SummaryDevelopment of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced bnAb lineage envelope binding and escape mutant neutralization—traits associated with increased B cell antigen drive. Thus, in this individual, two B cell lineages cooperated to induce the development of bnAbs. Design of vaccine immunogens that simultaneously drive both helper and broadly neutralizing B cell lineages may be important for vaccine-induced recapitulation of events that transpire during the maturation of neutralizing antibodies in HIV-1-infected individuals.
- Subjects :
- Models, Molecular
Immunogen
Lineage (evolution)
Mutant
Molecular Sequence Data
Biology
HIV Antibodies
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Virus
03 medical and health sciences
0302 clinical medicine
medicine
Amino Acid Sequence
B cell
030304 developmental biology
Immune Evasion
AIDS Vaccines
0303 health sciences
Mutation
B-Lymphocytes
Biochemistry, Genetics and Molecular Biology(all)
env Gene Products, Human Immunodeficiency Virus
Virology
Antibodies, Neutralizing
3. Good health
medicine.anatomical_structure
biology.protein
HIV-1
Antibody
Sequence Alignment
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 158
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....dd803b32b6f00331a86440a573610289
- Full Text :
- https://doi.org/10.1016/j.cell.2014.06.022