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The cornified envelope: a model of cell death in the skin
- Source :
- Nature reviews. Molecular cell biology. 6(4)
- Publication Year :
- 2005
-
Abstract
- The epidermis functions as a barrier against the environment by means of several layers of terminally differentiated, dead keratinocytes - the cornified layer, which forms the endpoint of epidermal differentiation and death. The cornified envelope replaces the plasma membrane of differentiating keratinocytes and consists of keratins that are enclosed within an insoluble amalgam of proteins, which are crosslinked by transglutaminases and surrounded by a lipid envelope. New insights into the molecular mechanisms and the physiological endpoints of cornification are increasing our understanding of the pathological defects of this unique form of programmed cell death, which is associated with barrier malfunctions and ichthyosis.
- Subjects :
- Apoptosis
Filaggrin Proteins
involucrin
skin lipid
Substrate Specificity
Intermediate Filament Proteins
loricrin
lipid metabolism
Keratin
amino acid composition
keratin
chemistry.chemical_classification
Settore BIO/11
protein arginine deiminase
Cell Differentiation
protein glutamine gamma glutamyltransferase
Cell biology
cell death
priority journal
Genetic Diseases
Loricrin
ichthyosis
cross linking
Programmed cell death
keratinization
review
keratinocyte
Biology
Cornified envelope
Viral envelope
medicine
Cell Adhesion
structural protein
Animals
Humans
Protein Precursors
Molecular Biology
Transglutaminases
Epidermis (botany)
profilaggrin
apoptosis
cell adhesion
cell differentiation
cell membrane
epidermis
protein analysis
Epidermis
Genetic Diseases, Inborn
Membrane Proteins
Cell Biology
medicine.disease
Inborn
chemistry
Epidermal Cells
Caspase 14
Ichthyosis vulgaris
Subjects
Details
- ISSN :
- 14710072
- Volume :
- 6
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nature reviews. Molecular cell biology
- Accession number :
- edsair.doi.dedup.....dd7ca2424ba5d50f4f4b77d28e37129f