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Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut
- Source :
- Differentiation; research in biological diversity. 75(5)
- Publication Year :
- 2007
-
Abstract
- The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (Alk) regulates a signal transduction pathway required for founder cell specification within the visceral muscle of the developing embryonic midgut. During embryonic development, the midgut visceral muscle is lined by the endodermal cell layer. In this paper, we have investigated signalling between these two tissues. Here, we show that Alk function is required for decapentaplegic (Dpp) expression and subsequent signalling via the Mad pathway in the developing gut. We propose that not only does Alk signalling regulate founder cell specification and thus fusion in the developing visceral muscle, but that Alk also regulates Dpp signalling between the visceral muscle and the endoderm. This provides an elegant mechanism with which to temporally coordinate visceral muscle fusion and later events in midgut development.
- Subjects :
- Cancer Research
medicine.medical_specialty
animal structures
Embryo, Nonmammalian
Biology
Mesoderm
hemic and lymphatic diseases
Internal medicine
medicine
Anaplastic lymphoma kinase
Animals
Drosophila Proteins
Anaplastic Lymphoma Kinase
Intestinal Mucosa
Molecular Biology
Ultrabithorax
Decapentaplegic
Embryogenesis
Endoderm
Gene Expression Regulation, Developmental
Receptor Protein-Tyrosine Kinases
Cell Biology
Protein-Tyrosine Kinases
biology.organism_classification
Embryonic stem cell
Cell biology
Intestines
Endocrinology
medicine.anatomical_structure
Drosophila melanogaster
Female
Signal transduction
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 03014681
- Volume :
- 75
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Differentiation; research in biological diversity
- Accession number :
- edsair.doi.dedup.....dd6ec681338b5139d3e38c81c79fb522