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Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses
- Source :
- FEBS Letters. 382:79-83
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- To study specific properties of the human gamma-interferon (gamma-IFN) receptor-like proteins of the highly virulent and low virulent strains of variola (smallpox) virus (VAR) recombinant plasmids determining synthesis of these proteins in E. coli cells have been constructed. The recombinant viral gamma-IFN receptor-like proteins have been found to have high interferon-neutralising activity with regard to human gamma-IFN but not murine gamma-IFN and human alpha-IFN. The variola major and variola minor proteins under study do not differ in the efficiency of human gamma-IFN antiviral activity inhibition.
- Subjects :
- Genes, Viral
Recombinant Fusion Proteins
viruses
Molecular Sequence Data
Biophysics
Alpha interferon
Virulence
Biology
complex mixtures
Biochemistry
Virus
law.invention
Microbiology
Interferon-gamma
Mice
Plasmid
Structural Biology
law
Gamma-interferon receptor
Escherichia coli
Genetics
medicine
Animals
Humans
Smallpox
Amino Acid Sequence
Smallpox virus
Molecular Biology
Receptors, Interferon
Viral Structural Proteins
Base Sequence
Sequence Homology, Amino Acid
Molecular factor of virulence
virus diseases
Variola virus
Cell Biology
medicine.disease
Virology
Recombinant DNA
Sequence Alignment
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 382
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....dd65fb6c0a24e813e6022c44d4ec5ccb