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Therapeutic Effects of Natural Drugs on Alzheimer’s Disease
- Source :
- Frontiers in Pharmacology, Vol 10 (2019), Frontiers in Pharmacology
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Alzheimer disease (AD) is characterized as a chronic neurodegenerative disease associated with aging. The clinical manifestations of AD include latent episodes of memory and cognitive impairment, psychiatric symptoms and behavioral disorders, as well as limited activities in daily life. In developed countries, AD is now acknowledged as the third leading cause of death, following cardiovascular disease and cancer. The pathogenesis and mechanism of AD remain unclear, although some theories have been proposed to explain AD, such as the theory of β-amyloid, the theory of the abnormal metabolism of tau protein, the theory of free radical damage, the theory of the inflammatory response, the theory of cholinergic damage, etc. Effective methods to predict, prevent or reverse AD are unavailable, and thus the development of new, efficient therapeutic drugs has become a current research hot spot worldwide. The isolation and extraction of active components from natural drugs have great potential in treating AD. These drugs possess the advantages of multiple targets in multiple pathways, fewer side effects and a long duration of curative effects. This article summaries the latest research progress regarding the mechanisms of natural drugs in the treatment of AD, providing a review of the literature and a theoretical basis for improving the clinical treatment of AD.
- Subjects :
- 0301 basic medicine
Tau protein
Review
Disease
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Medicine
Pharmacology (medical)
Cognitive impairment
free radical damage
Clinical treatment
natural drug
Free-radical theory of aging
Cause of death
Pharmacology
tau protein metabolism
biology
business.industry
β-amyloid
Therapeutic effect
lcsh:RM1-950
Alzheimer's disease
medicine.disease
030104 developmental biology
lcsh:Therapeutics. Pharmacology
030220 oncology & carcinogenesis
biology.protein
business
Subjects
Details
- Language :
- English
- ISSN :
- 16639812
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology
- Accession number :
- edsair.doi.dedup.....dd62f10f31895b41070ed9774dbdbe37