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Colorectal liver metastases:Surgery versus thermal ablation (COLLISION) - a phase III single-blind prospective randomized controlled trial
- Source :
- Puijk, R S, Ruarus, A H, Vroomen, L G P H, van Tilborg, A A J M, Scheffer, H J, Nielsen, K, de Jong, M C, de Vries, J J J, Zonderhuis, B M, Eker, H H, Kazemier, G, Verheul, H, van der Meijs, B B, van Dam, L, Sorgedrager, N, Coupé, V M H, van den Tol, P M P, Meijerink, M R & COLLISION Trial Group 2018, ' Colorectal liver metastases : Surgery versus thermal ablation (COLLISION)-a phase III single-blind prospective randomized controlled trial ', BMC Cancer, vol. 18, no. 1, 821 . https://doi.org/10.1186/s12885-018-4716-8, https://doi.org/10.1186/s12885-018-4716-8, BMC Cancer, 18(1):821. BioMed Central, BMC Cancer, 18(1):821. BioMed Central Ltd., BMC Cancer, 18, BMC Cancer, BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018), BMC cancer, 18(1):821. BioMed Central
- Publication Year :
- 2018
-
Abstract
- Contains fulltext : 195648.pdf (Publisher’s version ) (Open Access) BACKGROUND: Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal ablation inferior to surgical resection, the apparent selection bias when comparing patients with unresectable disease to surgical candidates, the superior safety profile, and the competitive overall survival results for the more recent reports mandate the setup of a randomized controlled trial. The objective of the COLLISION trial is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable CRLM and no extrahepatic disease. METHODS: In this two-arm, single-blind multi-center phase-III clinical trial, six hundred and eighteen patients with at least one CRLM (
- Subjects :
- Liver metastase
Male
Target lesion
Cancer Research
Colorectal cancer
Radiofrequency ablation
Colorectal Neoplasm
030230 surgery
law.invention
Study Protocol
Liver metastases
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Quality-Adjusted Life Year
Clinical endpoint
Medicine
Colorectal liver metastases (CRLM)
Liver Neoplasms
Microwave ablation
Microwave ablation (MWA)
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Treatment Outcome
Liver
Oncology
Liver Neoplasm
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
030220 oncology & carcinogenesis
Catheter Ablation
Female
Quality-Adjusted Life Years
Colorectal Neoplasms
Human
Adult
medicine.medical_specialty
lcsh:RC254-282
Disease-Free Survival
03 medical and health sciences
Genetic
Genetics
Humans
Hepatectomy
Liver surgery
Aged
business.industry
Radiofrequency ablation (RFA)
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
medicine.disease
Hepatic resection
Thermal ablation
Surgery
Clinical trial
business
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Database :
- OpenAIRE
- Journal :
- Puijk, R S, Ruarus, A H, Vroomen, L G P H, van Tilborg, A A J M, Scheffer, H J, Nielsen, K, de Jong, M C, de Vries, J J J, Zonderhuis, B M, Eker, H H, Kazemier, G, Verheul, H, van der Meijs, B B, van Dam, L, Sorgedrager, N, Coupé, V M H, van den Tol, P M P, Meijerink, M R & COLLISION Trial Group 2018, ' Colorectal liver metastases : Surgery versus thermal ablation (COLLISION)-a phase III single-blind prospective randomized controlled trial ', BMC Cancer, vol. 18, no. 1, 821 . https://doi.org/10.1186/s12885-018-4716-8, https://doi.org/10.1186/s12885-018-4716-8, BMC Cancer, 18(1):821. BioMed Central, BMC Cancer, 18(1):821. BioMed Central Ltd., BMC Cancer, 18, BMC Cancer, BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018), BMC cancer, 18(1):821. BioMed Central
- Accession number :
- edsair.doi.dedup.....dd5d347c59f4942cc0e83cfe3c564892
- Full Text :
- https://doi.org/10.1186/s12885-018-4716-8