Back to Search
Start Over
Cancer CXC chemokine networks and tumour angiogenesis
- Source :
- European journal of cancer (Oxford, England : 1990). 42(6)
- Publication Year :
- 2006
-
Abstract
- Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The glutamic acid-leucine-arginine (ELR+) CXC chemokines are potent promoters of angiogenesis, and mediate their angiogenic activity via signal-coupling of CXCR2 on endothelium. By contrast, members of the CXC chemokine family, such as platelet factor-4 (PF4; CXCL4) and interferon-inducible CXC chemokines are potent inhibitors of angiogenesis, and use CXCR3 on endothelium to mediate their angiostatic activity. This review will discuss the biology of CXC chemokines in the context of angiogenesis related to cancer.
- Subjects :
- Cancer Research
Immunity, Cellular
Neovascularization, Pathologic
Angiogenesis
hemic and immune systems
Angiogenesis Inhibitors
respiratory system
Biology
CXCR3
biological factors
CXCL1
CXCL2
Oncology
Neoplasms
Immunology
Angiostatic Proteins
Cancer research
CXCL9
CXCL10
Humans
CXC chemokine receptors
CXCL14
Chemokines, CXC
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 42
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Accession number :
- edsair.doi.dedup.....dd53b7813f5d28d2ce5044365abdd325