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The utility of International Society on Thrombosis and Haemostasis-Bleeding Assessment Tool and other bleeding questionnaires in assessing the bleeding phenotype in two platelet function defects
- Source :
- Blood Coagulation & Fibrinolysis. 27:589-593
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- The main objective of this study is to investigate the utility of International Society on Thrombosis and Haemostasis-Bleeding Assessment Tool (ISTH-BAT) in comparison with the condensed form of Molecular and Clinical Markers for the Diagnosis and Management of type 1 and WHO BATs, in assessing bleeding in two well known and clinically significant platelet function defects. Thirty-eight patients previously diagnosed with Glanzmann's thrombasthenia and 10 with Bernard-Soulier syndrome (BSS) were analyzed. Bleeding scores were significantly higher than that of controls using both electronic bleeding questionnaire (eBQ) and ISTH-BAT with no significant difference between both tools. ISTH-BAT had a sensitivity, specificity, positive predictive value and negative predictive value of 100%, 76.2%, 0.9 and 1. This was closely similar to eBQ. Both ISTH-BAT and eBQ are efficient in BSS and Glanzmann's thrombasthenia. However, given the ISTH recommendation, ISTH-BAT should be adopted. Larger study including other platelet defects will enhance its utility and support the integration of bleeding scores with standardized laboratory testing to allow for a universal diagnostic approach to patients with suspected bleeding disorders.
- Subjects :
- Adult
Blood Platelets
Male
medicine.medical_specialty
Adolescent
Hemorrhage
030204 cardiovascular system & hematology
Laboratory testing
Diagnostic Self Evaluation
03 medical and health sciences
0302 clinical medicine
Thrombasthenia
Surveys and Questionnaires
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Platelet
Child
business.industry
Significant difference
Case-control study
Bernard-Soulier Syndrome
Infant
Thrombosis
Hematology
General Medicine
Middle Aged
medicine.disease
Predictive value
Surgery
Case-Control Studies
Child, Preschool
Female
business
030215 immunology
Subjects
Details
- ISSN :
- 09575235
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Blood Coagulation & Fibrinolysis
- Accession number :
- edsair.doi.dedup.....dd3ffe2f47a1dd026ccd60121f8af600
- Full Text :
- https://doi.org/10.1097/mbc.0000000000000496