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Oxidative stress in severe acute illness
- Source :
- Redox Biology, Vol 4, Iss C, Pp 340-345 (2015), Redox Biology
- Publication Year :
- 2015
- Publisher :
- Elsevier, 2015.
-
Abstract
- The overall redox potential of a cell is primarily determined by oxidizable/reducible chemical pairs, including glutathione–glutathione disulfide, reduced thioredoxin–oxidized thioredoxin, and NAD+–NADH (and NADP–NADPH). Current methods for evaluating oxidative stress rely on detecting levels of individual byproducts of oxidative damage or by determining the total levels or activity of individual antioxidant enzymes. Oxidation–reduction potential (ORP), on the other hand, is an integrated, comprehensive measure of the balance between total (known and unknown) pro-oxidant and antioxidant components in a biological system. Much emphasis has been placed on the role of oxidative stress in chronic diseases, such as Alzheimer's disease and atherosclerosis. The role of oxidative stress in acute diseases often seen in the emergency room and intensive care unit is considerable. New tools for the rapid, inexpensive measurement of both redox potential and total redox capacity should aid in introducing a new body of literature on the role of oxidative stress in acute illness and how to screen and monitor for potentially beneficial pharmacologic agents.<br />Graphical abstact
- Subjects :
- Antioxidant
Mini Review
medicine.medical_treatment
Oxidation reduction potential
Clinical Biochemistry
Myocardial Infarction
Disease
Superoxide dismutase
medicine.disease_cause
Bioinformatics
Biochemistry
Antioxidants
4-Hydroxynonenal
chemistry.chemical_compound
Thioredoxins
Traumatic brain injury
Sepsis
Malondialdehyde
Humans
Medicine
Hypoxia-inducible factor 1
lcsh:QH301-705.5
Glutathione Peroxidase
lcsh:R5-920
biology
Multiple Trauma
business.industry
Organic Chemistry
NAD
Glutathione
Stroke
Oxidative Stress
Glutathione Reductase
chemistry
lcsh:Biology (General)
Brain Injuries
Acute Disease
biology.protein
NAD+ kinase
Thioredoxin
Reactive Oxygen Species
business
lcsh:Medicine (General)
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....dd3fc00518625af73d9cb83667b4cb62