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Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Low-temperature plasma is being widely used in the various fields of life science, such as medicine and agriculture. Plasma-activated solutions have been proposed as potential cancer therapeutic reagents. We previously reported that plasma-activated Ringer’s lactate solution exhibited selective cancer-killing effects, and that the plasma-treated L-sodium lactate in the solution was an anti-tumor factor; however, the components that are generated through the interactions between plasma and L-sodium lactate and the components responsible for the selective killing of cancer cells remain unidentified. In this study, we quantified several major chemical products, such as pyruvate, formate, and acetate, in plasma-activated L-sodium lactate solution by nuclear magnetic resonance analysis. We further identified novel chemical products, such as glyoxylate and 2,3-dimethyltartrate, in the solution by direct infusion-electrospray ionization with tandem mass spectrometry analysis. We found that 2,3-dimethyltartrate exhibited cytotoxic effects in glioblastoma cells, but not in normal astrocytes. These findings shed light on the identities of the components that are responsible for the selective cytotoxic effect of plasma-activated solutions on cancer cells, and provide useful data for the potential development of cancer treatments using plasma-activated L-sodium lactate solution.
- Subjects :
- Programmed cell death
Cell biology
Formates
Plasma Gases
Science
Glyoxylate cycle
Tandem mass spectrometry
Biochemistry
Article
Sodium Lactate
chemistry.chemical_compound
Engineering
Cell Line, Tumor
Pyruvic Acid
Sodium lactate
medicine
Cytotoxic T cell
Humans
Formate
Tartrates
Cancer
Multidisciplinary
Cell Death
Brain Neoplasms
Glyoxylates
medicine.disease
Chemical biology
chemistry
Cancer cell
Medicine
Glioblastoma
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....dd3f0410aef2c6b0ceb43129b9661db5