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Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
- Source :
- Nature Communications, Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩, Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩, Molinaro, A, Bel Lassen, P, Henricsson, M, Wu, H, Adriouch, S, Belda, E, Chakaroun, R, Nielsen, T, Bergh, P-O, Rouault, C, Andre, S, Marquet, F, Andreelli, F, Salem, J-E, Assmann, K, Bastard, J-P, Forslund, S, Le Chatelier, E, Falony, G, Pons, N, Prifti, E, Quinquis, B, Roume, H, Vieira-Silva, S, Hansen, T H, Pedersen, H K, Lewinter, C, Sønderskov, N B, Køber, L, Vestergaard, H, Hansen, T, Zucker, J-D, Galan, P, Dumas, M-E, Raes, J, Oppert, J-M, Letunic, I, Nielsen, J, Bork, P, Ehrlich, S D, Stumvoll, M, Pedersen, O, Aron-Wisneswky, J, Clement, K, Baeckhed, F & MetaCardis Consortium 2020, ' Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology ', Nature Communications, vol. 11, no. 1, 5881 . https://doi.org/10.1038/s41467-020-19589-w, Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.<br />Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.
- Subjects :
- 0301 basic medicine
Male
ACCURATE METHOD
endocrine system diseases
Metabolite
[SDV]Life Sciences [q-bio]
General Physics and Astronomy
Type 2 diabetes
GUT MICROBIOME
GLUCOSE
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
[CHIM] Chemical Sciences
Prediabetes
lcsh:Science
2. Zero hunger
RISK
Multidisciplinary
biology
INSULIN SENSITIVITY
Imidazoles
HOMEOSTASIS MODEL ASSESSMENT
Middle Aged
3. Good health
Multidisciplinary Sciences
[SDV] Life Sciences [q-bio]
030220 oncology & carcinogenesis
Science & Technology - Other Topics
Enterotype
Female
Adult
medicine.medical_specialty
Science
Carbohydrate metabolism
Microbiology
digestive system
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
INTESTINAL MICROBIOTA
Internal medicine
medicine
Humans
[CHIM]Chemical Sciences
Histidine
Author Correction
PHYSIOLOGY
Aged
Science & Technology
Bacteria
General Chemistry
Metabolism
medicine.disease
biology.organism_classification
Gastrointestinal Microbiome
MetaCardis Consortium
METAGENOME
INDIVIDUALS
030104 developmental biology
chemistry
Diabetes Mellitus, Type 2
Cardiovascular and Metabolic Diseases
lcsh:Q
Bacteroides
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩, Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-19589-w⟩, Molinaro, A, Bel Lassen, P, Henricsson, M, Wu, H, Adriouch, S, Belda, E, Chakaroun, R, Nielsen, T, Bergh, P-O, Rouault, C, Andre, S, Marquet, F, Andreelli, F, Salem, J-E, Assmann, K, Bastard, J-P, Forslund, S, Le Chatelier, E, Falony, G, Pons, N, Prifti, E, Quinquis, B, Roume, H, Vieira-Silva, S, Hansen, T H, Pedersen, H K, Lewinter, C, Sønderskov, N B, Køber, L, Vestergaard, H, Hansen, T, Zucker, J-D, Galan, P, Dumas, M-E, Raes, J, Oppert, J-M, Letunic, I, Nielsen, J, Bork, P, Ehrlich, S D, Stumvoll, M, Pedersen, O, Aron-Wisneswky, J, Clement, K, Baeckhed, F & MetaCardis Consortium 2020, ' Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology ', Nature Communications, vol. 11, no. 1, 5881 . https://doi.org/10.1038/s41467-020-19589-w, Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
- Accession number :
- edsair.doi.dedup.....dd3c75590cc839824fb6e12f5fcd3c5d