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The TNFA -857C/T Polymorphism: Association with Rheumatoid Arthritis and Anti-CCP Levels in a Mexican Population
- Source :
- Journal of Immunology Research, Vol 2019 (2019), Journal of Immunology Research
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Rheumatoid arthritis (RA) is a chronic inflammatory disease whose association with SNPs has led to the identification of biomarkers in different populations. To determine the association of the -857C/T SNP of the TNFA gene with RA and clinical parameters, 233 RA patients and 237 healthy controls were included in this study. The -857C/T polymorphism was determined using the TaqMan® system and clinical features were also determined. We found that the -857C/T SNP was in Hardy-Weinberg equilibrium. Our results showed no association of the -857C/T SNP with RA; however, RA patients carrying the TT genotype showed lower anti-CCP levels than other groups. Therefore, the TT genotype could be a risk factor for developing anti-CCP-negative RA. Our results suggest that the T allele of the TNFA -857C/T SNP exerts an influence on anti-CCP levels and could be a candidate marker for anti-CCP-negative RA.
- Subjects :
- Adult
Male
musculoskeletal diseases
lcsh:Immunologic diseases. Allergy
Article Subject
Genotype
Immunology
Arthritis
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Anti-Citrullinated Protein Antibodies
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Odds Ratio
Humans
Immunology and Allergy
Medicine
SNP
Genetic Predisposition to Disease
Allele
Mexico
Allele frequency
Alleles
Aged
030304 developmental biology
030203 arthritis & rheumatology
0303 health sciences
Tumor Necrosis Factor-alpha
business.industry
Case-control study
General Medicine
Middle Aged
medicine.disease
Case-Control Studies
Population Surveillance
Rheumatoid arthritis
Female
lcsh:RC581-607
business
Research Article
Subjects
Details
- ISSN :
- 23147156 and 23148861
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....dd36b7d9e237dd1feac1f63d3f8a4d46