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Orally Efficacious NR2B-Selective NMDA Receptor Antagonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 13:697-700
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- A novel series of benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 31 is orally active in a carrageenan-induced rat hyperalgesia model of pain and shows no motor coordination side effects.
- Subjects :
- Clinical Biochemistry
Analgesic
Drug Evaluation, Preclinical
Administration, Oral
Pain
Pharmaceutical Science
Pharmacology
Carrageenan
Receptors, N-Methyl-D-Aspartate
Biochemistry
Structure-Activity Relationship
Oral administration
Drug Discovery
medicine
Animals
Molecular Biology
Chemistry
Organic Chemistry
Glutamate receptor
Antagonist
Benzamidines
Rats
Motor coordination
nervous system
Hyperalgesia
Molecular Medicine
NMDA receptor
medicine.symptom
Psychomotor Performance
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....dd299167537625261e03641a62d5a8a0
- Full Text :
- https://doi.org/10.1016/s0960-894x(02)01061-2