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Liquid biopsy tracking of lung tumor evolutions over time
- Source :
- Expert Review of Molecular Diagnostics. 19:1099-1108
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Introduction: The rise of the personalized era in lung cancer prompted the evaluation of novel diagnostic tools to overcome some of the limits of traditional tumor genotyping. Liquid biopsy refers to a multitude of minimally invasive techniques that can allow a real-time biomolecular characterization of the tumor through the analysis of human body fluids. Areas covered: Herein we provide a comprehensive overview of the role of liquid biopsy in lung cancer, mainly focusing on the most studied members of the liquid biopsy family, cell-free DNA (cfDNA) and circulating tumor cells (CTCs). Expert opinion: Among the different components of the large liquid biopsy family, cfDNA is the most studied and widely adopted source for tumor genotyping in lung cancer, already entered clinical practice for detection of both sensitizing and resistance EGFR mutations. However, the impressive technological advances made in the last few years are expanding its potential applications, allowing a more comprehensive plasma genotyping through next-generation sequencing and moving from advanced/metastatic disease to novel frontiers, such as early detection and minimal residual disease evaluation.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Lung Neoplasms
Genotyping Techniques
EGFR
NSCLC
Diagnostic tools
circulating tumor cell
Circulating Tumor DNA
Pathology and Forensic Medicine
03 medical and health sciences
ALK, bTMB, cfDNA, circulating tumor cells, EGFR, liquid biopsy, NGS, NSCLC, real-time PCR
SCLC, Biomarkers, Tumor, Circulating Tumor DNA, Genetic Testing, Genotyping Techniques, Humans, Liquid Biopsy, Lung Neoplasms, Neoplastic Cells, Circulating
0302 clinical medicine
Circulating tumor cell
Biomarkers, Tumor
Genetics
medicine
Humans
Genetic Testing
cfDNA
Liquid biopsy
Lung cancer
Molecular Biology
Genotyping
liquid biopsy
business.industry
SCLC
Neoplastic Cells, Circulating
medicine.disease
bTMB
030104 developmental biology
Real-time polymerase chain reaction
ALK
NGS
030220 oncology & carcinogenesis
Molecular Medicine
Lung tumor
real-time PCR
business
Subjects
Details
- ISSN :
- 17448352 and 14737159
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Expert Review of Molecular Diagnostics
- Accession number :
- edsair.doi.dedup.....dd17d7edab1c44b4d35963d266fa6d4f