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Impact of body mass index on pathological complete response following neoadjuvant chemotherapy in operable breast cancer: a meta-analysis
- Source :
- Breast cancer (Tokyo, Japan). 28(3)
- Publication Year :
- 2020
-
Abstract
- The impact of an increased body mass index (BMI) on outcomes of neoadjuvant chemotherapy (NACT) in breast cancer remains controversial. The purpose of this study was to analyze the impact of BMI on pathological complete response (pCR) rates for operable breast cancer after NACT. We searched Medline, Embase, and Web of Science database for observational studies and randomized controlled trials that reported the association of BMI with pCR after NACT. We performed a meta-analysis to assess the impact of BMI on pCR rate. We identified 13 studies including a total of 18,702 women with operable breast cancer who underwent NACT. Two studies were pooled analyses of prospective clinical trials (10,669 patients); the rest were case–control studies (8033 patients). All studies provided data of two BMI groups (BMI
- Subjects :
- 0301 basic medicine
Oncology
Adult
medicine.medical_specialty
Breast Neoplasms
Overweight
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Pharmacology (medical)
Radiology, Nuclear Medicine and imaging
Obesity
Prospective cohort study
business.industry
nutritional and metabolic diseases
General Medicine
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Neoadjuvant Therapy
Clinical trial
030104 developmental biology
Treatment Outcome
030220 oncology & carcinogenesis
Meta-analysis
Female
medicine.symptom
business
Body mass index
Subjects
Details
- ISSN :
- 18804233
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Breast cancer (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....dd11e0fe16541f7d659832dd2421e607