Back to Search
Start Over
Activity of Meropenem-Vaborbactam against Pseudomonas aeruginosa and Acinetobacter baumannii in a Neutropenic Mouse Thigh Infection Model
- Publication Year :
- 2018
- Publisher :
- American Society for Microbiology, 2018.
-
Abstract
- We have evaluated the activity of meropenem-vaborbactam against clinical isolates of Pseudomonas aeruginosa and Acinetobacter baumannii in a neutropenic mouse thigh infection model. Data show that meropenem-vaborbactam regimens equivalent to 3-h infusions every 8 h with 2 g meropenem and 2 g vaborbactam produced bacterial killing against strains with MICs of 2 to 16 mg/liter and suggests that this combination may have utility in the treatment of infections caused by P. aeruginosa and A. baumannii .
- Subjects :
- Acinetobacter baumannii
Bacterial killing
Microbial Sensitivity Tests
medicine.disease_cause
Meropenem
Microbiology
03 medical and health sciences
Heterocyclic Compounds, 1-Ring
Mice
Drug Resistance, Multiple, Bacterial
polycyclic compounds
Medicine
Animals
Humans
Pharmacology (medical)
Experimental Therapeutics
Pseudomonas Infections
A baumannii
Pharmacology
0303 health sciences
Vaborbactam
biology
030306 microbiology
business.industry
Pseudomonas aeruginosa
Meropenem+Vaborbactam
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
bacterial infections and mycoses
Boronic Acids
Anti-Bacterial Agents
Drug Combinations
Infectious Diseases
Carbapenem-Resistant Enterobacteriaceae
bacteria
Female
business
medicine.drug
Acinetobacter Infections
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....dcedd960c024d953fe0ca6dacec4d102