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Malaria Is Associated With Kaposi Sarcoma-Associated Herpesvirus Seroconversion in a Cohort of Western Kenyan Children
- Source :
- J Infect Dis
- Publication Year :
- 2020
-
Abstract
- Background We aimed to determine whether Plasmodium falciparum infection affects age of Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion in Kenyan children. Methods Kenyan children (n = 144) enrolled at age 1 month, from 2 sites with different levels of malaria transmission (stable/high vs unstable/low) were followed to age 24 months. Plasma was tested for KSHV antibodies using enzyme-linked immunosorbent assay (ELISA; K8.1 and LANA) and a multiplex bead-based assay (K8.1, K10.5, ORF38, ORF50, and LANA) and whole blood tested for P. falciparum DNA using quantitative PCR. Cox proportional hazards models were used to assess associations between P. falciparum DNA detection, malaria annualized rate (P. falciparum detections/person-years), and enrollment site (malaria-high vs malaria-low) with time to KSHV seroconversion. Results KSHV seroprevalence was 63% by age 2 years when assessed by multiplex assay. Children with P. falciparum were at increased hazards of earlier KSHV seroconversion and, among children with malaria, the hazard of becoming KSHV seropositive increased significantly with increasing malaria annualized rate. Children from the malaria-high transmission region had no significant difference in hazards of KSHV seroconversion at 12 months but were more likely to become KSHV seropositive by age 24 months. Discussion Malaria exposure increases the risk for KSHV seroconversion early in life.
- Subjects :
- viruses
Antibodies, Viral
Major Articles and Brief Reports
Seroepidemiologic Studies
parasitic diseases
Immunology and Allergy
Medicine
Seroprevalence
Humans
Seroconversion
Sarcoma, Kaposi
biology
Proportional hazards model
business.industry
Transmission (medicine)
virus diseases
Infant
Plasmodium falciparum
biochemical phenomena, metabolism, and nutrition
medicine.disease
biology.organism_classification
Virology
Kenya
Malaria
Infectious Diseases
Child, Preschool
Cohort
Herpesvirus 8, Human
biology.protein
Antibody
business
Subjects
Details
- ISSN :
- 15376613
- Volume :
- 224
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....dce92814e891ab1662ec1e1e5f6d413c