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In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

Authors :
Antje Knopf
Marc-Jan van Goethem
Harry Kiewit
Johannes A. Langendijk
Sytze Brandenburg
Robert P. Coppes
Marco Kempers
Peter W. Nagle
Peter van Luijk
Research unit Medical Physics
Damage and Repair in Cancer Development and Cancer Treatment (DARE)
Guided Treatment in Optimal Selected Cancer Patients (GUTS)
Source :
Radiotherapy and Oncology, 137, 125-129. ELSEVIER IRELAND LTD
Publication Year :
2019
Publisher :
ELSEVIER IRELAND LTD, 2019.

Abstract

To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response. (C) 2019 Elsevier B.V. All rights reserved.

Details

Language :
English
ISSN :
18790887 and 01678140
Volume :
137
Database :
OpenAIRE
Journal :
Radiotherapy and Oncology
Accession number :
edsair.doi.dedup.....dce54fbf73a29c8b0f7893fa0395ef65