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Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
- Source :
- Cells, Cells, Vol 9, Iss 956, p 956 (2020)
- Publication Year :
- 2020
- Publisher :
- Preprints, 2020.
-
Abstract
- Many ligands directly target adenosine receptors (ARs). Here we review the effects of noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms include raising adenosine levels by inhibiting adenosine transport (e.g., ticagrelor, ethanol, and cannabidiol), affecting intracellular metabolic pathways (e.g., methotrexate, nicotinamide riboside, salicylate, and 5-aminoimidazole-4-carboxamide riboside), or undetermined means (e.g., acupuncture). However, other compounds bind ARs in addition to their canonical ‘on-target’ activity (e.g., mefloquine). The strength of experimental support for an adenosine-related role in a drug’s effects varies widely. AR knockout mice are the ‘gold standard’ method for investigating an AR role, but few drugs have been tested on these mice. Given the interest in AR modulation for treatment of cancer, CNS, immune, metabolic, cardiovascular, and musculoskeletal conditions, it is informative to consider AR and non-AR adenosinergic effects of approved drugs and conventional treatments.
- Subjects :
- Drug
media_common.quotation_subject
Adenosinergic
Review
Pharmacology
pharmacology_toxicology
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
medicine
Animals
Humans
pain
adenosine receptor
lcsh:QH301-705.5
030304 developmental biology
media_common
0303 health sciences
Adenosine transport
Receptors, Purinergic P1
General Medicine
Riboside
Adenosine receptor
Adenosine
3. Good health
lcsh:Biology (General)
chemistry
Pharmaceutical Preparations
inflammation
Nicotinamide riboside
cardiovascular system
nucleoside transport
CNS
Cannabidiol
030217 neurology & neurosurgery
medicine.drug
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cells, Cells, Vol 9, Iss 956, p 956 (2020)
- Accession number :
- edsair.doi.dedup.....dcc21832bf81f6e47997f3af74b8a012