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Outcome of pregnancy with new onset proteinuria and progression to pre-eclampsia: A retrospective analysis
- Source :
- Pregnancy Hypertension. 12:174-177
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objective To examine maternal and neonatal outcomes of gestational proteinuria, and to identify maternal characteristics for progression to pre-eclampsia. Study design Retrospective cohort. Included all pregnant women who delivered between Jan 2014–Feb 2017 with new onset proteinuria in a single obstetric unit. Demographic, maternal and neonatal outcomes were compared. Results Eighteen (25%) out of 73 women with new onset gestational proteinuria developed pre-eclampsia. The incidence of gestational proteinuria was 0.54%. Compared with women that remained normotensive, those that developed hypertension had delivery at earlier gestation (p = .02), increased risk of fetal growth restriction (p = .01) and lower newborn birthweight (p = .002). Maximal proteinuria and fetal growth restriction were independent factors associated with development of pre-eclampsia. In particular, high proteinuria level ≥ 2 g/d constitute a major predictor for progression (p = .03). Conclusion Increased vigilance for antenatal surveillance is important in women with gestational proteinuria as a substantial portion progress to pre-eclampsia. Serial growth scan and proteinuria assay are suggested to predict possible pre-eclampsia development.
- Subjects :
- Adult
medicine.medical_specialty
Blood Pressure
Gestational Age
Kidney
urologic and male genital diseases
New onset
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Risk Factors
Internal Medicine
Retrospective analysis
Birth Weight
Humans
Medicine
Gestational proteinuria
030212 general & internal medicine
reproductive and urinary physiology
Retrospective Studies
Fetal Growth Retardation
030219 obstetrics & reproductive medicine
Proteinuria
Eclampsia
business.industry
Obstetrics
Incidence
Obstetrics and Gynecology
Retrospective cohort study
Infant, Low Birth Weight
medicine.disease
female genital diseases and pregnancy complications
Disease Progression
Hong Kong
Premature Birth
Gestation
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 22107789
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Pregnancy Hypertension
- Accession number :
- edsair.doi.dedup.....dcbb0a7613db9d857352bcbece86c3b7