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Bionic Dormant Body of Timed Wake-Up for Bacteriotherapy in Vivo

Bionic Dormant Body of Timed Wake-Up for Bacteriotherapy in Vivo

Authors :
Mingming Guo
Chunrui Yang
Bowen Li
Shi-Xiang Cheng
Qinglu Guo
Dong Ming
Bin Zheng
Source :
ACS Nano. 16:823-836
Publication Year :
2022
Publisher :
American Chemical Society (ACS), 2022.

Abstract

The microorganism has become a promising therapeutic tool for many diseases because it is a kind of cell factory that can efficiently synthesize a variety of bioactive substances. However, the metabolic destiny of microorganisms is difficult to predictiin vivo/i. Here, a timing bionic dormant body with programmable destiny is reported, which can predict the metabolic time and location of microorganismsiin vivo/iand can prevent it from being damaged by the complex biological environmentiin vivo/i. Taking the complex digestive system as an example, the bionic dormant body exists in the upper digestive tract as a nonmetabolic dormant body after oral administration and will be awakened to synthesize bioactive substances about 2 h after reaching the intestine. Compared with oral microorganisms alone, the bioavailability of the biomimetic dormant body in the intestine is almost 3.5 times higher. The utilization rate of the oral bionic dormant body to synthesize drugs is 2.28 times higher than oral drugs. We demonstrated the significant efficacies of treatment using Parkinson's disease (PD) mice by dormant body capable of timed neurotransmitter production after oral delivery. The timed bionic dormant body with programmable destiny may provide an effective technology to generate advanced microbial therapies for the treatment of various diseases.

Details

ISSN :
1936086X and 19360851
Volume :
16
Database :
OpenAIRE
Journal :
ACS Nano
Accession number :
edsair.doi.dedup.....dcb5b0c8c544b3b2e30488e61d84f2e7
Full Text :
https://doi.org/10.1021/acsnano.1c08377