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Effects of a single bout of interval hypoxia on cardiorespiratory control in patients with type 1 diabetes
- Source :
- Diabetes
- Publication Year :
- 2013
-
Abstract
- Hypoxemia is common in diabetes, and reflex responses to hypoxia are blunted. These abnormalities could lead to cardiovascular/renal complications. Interval hypoxia (IH) (5–6 short periods of hypoxia each day over 1–3 weeks) was successfully used to improve the adaptation to hypoxia in patients with chronic obstructive pulmonary disease. We tested whether IH over 1 day could initiate a long-lasting response potentially leading to better adaptation to hypoxia. In 15 patients with type 1 diabetes, we measured hypoxic and hypercapnic ventilatory responses (HCVRs), ventilatory recruitment threshold (VRT-CO2), baroreflex sensitivity (BRS), blood pressure, and blood lactate before and after 0, 3, and 6 h of a 1-h single bout of IH. All measurements were repeated on a placebo day (single-blind protocol, randomized sequence). After IH (immediately and after 3 h), hypoxic and HCVR increased, whereas the VRT-CO2 dropped. No such changes were observed on the placebo day. Systolic and diastolic blood pressure increased, whereas blood lactate decreased after IH. Despite exposure to hypoxia, BRS remained unchanged. Repeated exposures to hypoxia over 1 day induced an initial adaptation to hypoxia, with improvement in respiratory reflexes. Prolonging the exposure to IH (>2 weeks) in type 1 diabetic patients will be a matter for further studies.
- Subjects :
- Adult
Male
Complications
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Blood Pressure
030204 cardiovascular system & hematology
Baroreflex
Hypoxemia
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Single-Blind Method
Hypoxia
Original Research
Type 1 diabetes
business.industry
Respiration
Cardiorespiratory fitness
Hypoxia (medical)
medicine.disease
Adaptation, Physiological
3. Good health
Blood pressure
Diabetes Mellitus, Type 1
Anesthesia
Female
medicine.symptom
business
Hypercapnia
Subjects
Details
- ISSN :
- 1939327X
- Volume :
- 62
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....dcb357be151c5fd7390c5feec1080f72