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Open field behaviour in rats; role of metabotropic glutamate receptors
- Source :
- NeuroReport. 6:2389-2393
- Publication Year :
- 1995
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1995.
-
Abstract
- Previous studies have shown that spatial memory retention is affected by the metabotropic glutamate receptor (mGluR) influencing agents (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and trans-azetidine-2,4-dicarboxylic acid (tADA). In the present investigation we examined whether the mGluR antagonist MCPG (20 mM and 200 mM/5 microliters, respectively) and the agonist tADA (20 mM/5 microliters) have other behavioural effects using the open field test on two successive days. Only minor effects of MCPG (decrease of crossings during the 1st min on day 1) and tADA (increase of rearings on both days) were found. These results suggest that memory influencing doses of MCPG and tADA have no or only little behavioural effects in the open field situation.
- Subjects :
- Male
Agonist
medicine.medical_specialty
medicine.drug_class
Glycine
Motor Activity
Receptors, Metabotropic Glutamate
Benzoates
Open field
chemistry.chemical_compound
Internal medicine
Cyclic AMP
Excitatory Amino Acid Agonists
medicine
Animals
Rats, Wistar
Excitatory Amino Acid Agonist
Injections, Intraventricular
Behavior, Animal
General Neuroscience
Glutamate receptor
Antagonist
Rats
Metabotropic receptor
Endocrinology
chemistry
Metabotropic glutamate receptor
Space Perception
Type C Phospholipases
Azetidinecarboxylic Acid
Excitatory Amino Acid Antagonists
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- NeuroReport
- Accession number :
- edsair.doi.dedup.....dcb0c194518306799604ee096e38f6a2