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Ultra-thin rigid endoscope: Two-photon imaging through a graded-index multi-mode fiber

Authors :
Géraud Bouwmans
Esben Ravn Andresen
Serge Monneret
Siddharth Sivankutty
Rosa Cossart
Hervé Rigneault
MOSAIC (MOSAIC)
Institut FRESNEL (FRESNEL)
Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Epilepsie et ischémie cérébrale
Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM)
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM)
Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)
Source :
Optics Express, Optics Express, 2016, 24, pp.825-841. ⟨10.1364/OE.24.000825⟩, Optics Express, Optical Society of America-OSA Publishing, 2016, 24, pp.825-841. ⟨10.1364/OE.24.000825⟩
Publication Year :
2015

Abstract

Rigid endoscopes like graded-index (GRIN) lenses are known tools in biological imaging, but it is conceptually difficult to miniaturize them. In this letter, we demonstrate an ultra-thin rigid endoscope with a diameter of only 125 microns. In addition, we identify a domain where two-photon endoscopic imaging with fs-pulse excitation is possible. We validate the ultra-thin rigid endoscope consisting of a few cm of graded-index multi-mode fiber by using it to acquire optically sectioned two-photon fluorescence endoscopic images of three-dimensional samples.<br />17 pages, 15 figures, submitted to Opt. Express

Subjects

Subjects :
Diagnostic Imaging
Optical fiber
Materials science
Physics - Instrumentation and Detectors
genetic structures
Physics::Medical Physics
FOS: Physical sciences
Physics::Optics
02 engineering and technology
01 natural sciences
law.invention
010309 optics
Computer Science::Robotics
Imaging, Three-Dimensional
Optics
Two-photon excitation microscopy
law
Rigid endoscope
0103 physical sciences
Fiber
Mathematics::Representation Theory
ComputingMilieux_MISCELLANEOUS
Endoscopes
Photons
Multi-mode optical fiber
business.industry
Lasers
Instrumentation and Detectors (physics.ins-det)
021001 nanoscience & nanotechnology
Atomic and Molecular Physics, and Optics
[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Spatial frequency
Speckle imaging
0210 nano-technology
business
Biological imaging
Optics (physics.optics)
Physics - Optics

Details

Language :
English
ISSN :
10944087
Database :
OpenAIRE
Journal :
Optics Express, Optics Express, 2016, 24, pp.825-841. ⟨10.1364/OE.24.000825⟩, Optics Express, Optical Society of America-OSA Publishing, 2016, 24, pp.825-841. ⟨10.1364/OE.24.000825⟩
Accession number :
edsair.doi.dedup.....dca730d8d4243e0f11df695203886580

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Authors Abstract Subjects Details