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Two new triterpenoids from the roots of Phyllanthus emblica
- Source :
- Fitoterapia. 130
- Publication Year :
- 2018
-
Abstract
- Two new triterpenes, the seco-friedelane type secofriedelanophyllemblicine and the ursane-derived saponin ursophyllemblicoside were isolated from the roots of the edible fruit-producing Phyllanthus emblica. Their structures were unambiguously elucidated using extensive 1D and 2D NMR analyses, high resolution mass spectrometry and single-crystal X-ray crystallographic analyses along with comparison with literature data. Secofriedelanophyllemblicine represents the first 3,4-secofriedelane bearing a carboxylic acid group substituent at C-20. Ursophyllemblicoside, incorporating the rare 21α hydroxyursolic acid as a sapogenol represents the first example of saponin comprising this aglycone. Secofriedelanophyllemblicine displayed a moderate cytotoxicity against K562 and HepG2 cancer cell lines.
- Subjects :
- Stereochemistry
Carboxylic acid
Phytochemicals
Saponin
Substituent
Phyllanthus emblica
01 natural sciences
Plant Roots
Terpene
chemistry.chemical_compound
Triterpene
Drug Discovery
Humans
Pharmacology
chemistry.chemical_classification
Molecular Structure
010405 organic chemistry
General Medicine
Hep G2 Cells
Saponins
Antineoplastic Agents, Phytogenic
Triterpenes
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Aglycone
chemistry
Vietnam
K562 Cells
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- ISSN :
- 18736971
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....dca5a595a832274ac2794efaaed0c92d