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Sentinel lymph node biopsy can be omitted in DCIS patients treated with breast conserving therapy
- Source :
- Breast Cancer Research and Treatment, 156(3), 517-525. Springer, Cham, Breast Cancer Research and Treatment
- Publication Year :
- 2016
- Publisher :
- Springer, Cham, 2016.
-
Abstract
- Breast cancer guidelines advise sentinel lymph node biopsy (SLNB) in patients with ductal carcinoma in situ (DCIS) on core biopsy at high risk of invasive cancer or in case of mastectomy. This study investigates the incidence of SLNB and SLN metastases and the relevance of indications in guidelines and literature to perform SLNB in order to validate whether SLNB is justified in patients with DCIS on core biopsy in current era. Clinically node negative patients diagnosed from 2004 to 2013 with only DCIS on core needle biopsy were selected from a national database. Incidence of SLN biopsy and metastases was calculated. With Fisher exact tests correlation between SLNB indications and actual presence of SLN metastases was studied. Further, underestimation rate for invasive cancer and correlation with SLN metastases was analysed. 910 patients were included. SLNB was performed in 471 patients (51.8 %): 94.5 % had pN0, 3.0 % pN1mi and 2.5 % pN1. Patients undergoing mastectomy had 7 % SLN metastases versus 3.5 % for breast conserving surgery (BCS) (p = 0.107). The only factors correlating to SLN metastases were smaller core needle size (p = 0.01) and invasive cancer (p
- Subjects :
- Adult
Cancer Research
medicine.medical_specialty
DCIS
medicine.medical_treatment
Sentinel lymph node
Breast Neoplasms
030230 surgery
Mastectomy, Segmental
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Breast cancer
Sentinel lymph node biopsy
Risk Factors
Biopsy
medicine
Breast-conserving surgery
Humans
Neoplasm Invasiveness
Fisher's exact test
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Incidence
Middle Aged
Ductal carcinoma
medicine.disease
Clinical Trial
Surgery
Treatment
Carcinoma, Intraductal, Noninfiltrating
Oncology
Lymphatic Metastasis
030220 oncology & carcinogenesis
Practice Guidelines as Topic
symbols
Female
Histopathology
Sentinel Lymph Node
business
Mastectomy
Subjects
Details
- Language :
- English
- ISSN :
- 15737217 and 01676806
- Volume :
- 156
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....dc9a13ef8b054c661cd8aec7fc05b48e