Back to Search
Start Over
Annual change in plasma xanthine oxidoreductase activity is associated with changes in liver enzymes and body weight
- Source :
- Endocrine Journal. 66:777-786
- Publication Year :
- 2019
- Publisher :
- Japan Endocrine Society, 2019.
-
Abstract
- Xanthine oxidoreductase (XOR), an enzyme of uric acid formation from hypoxanthine and xanthine, is recognized as a source of oxidative stress. Plasma activity of XOR has been reported to be a biomarker of metabolic disorders associated with obesity, liver dysfunction, insulin resistance, hyperuricemia and adipokines. We investigated longitudinal change in plasma XOR activity, which was determined by using mass spectrometry and liquid chromatography to detect [13C2, 15N2]-uric acid using [13C2, 15N2]-xanthine as a substrate, in 511 subjects (male/female: 244/267) of the Tanno-Sobetsu Study in the years 2016 and 2017. Plasma XOR activity in a basal state was significantly higher in men than in women, but no significant sex difference was observed in annual change in plasma XOR activity. Annual change in plasma activity of XOR was positively correlated with changes in each parameter, including body weight (r = 0.203, p < 0.001), body mass index, diastolic blood pressure, aspartate transaminase (AST) (r = 0.772, p < 0.001), alanine transaminase (r = 0.647, p < 0.001), γ-glutamyl transpeptidase, total cholesterol, triglycerides, uric acid, fasting glucose and HbA1c. Multivariate regression analysis demonstrated that change in AST and that in body weight were independent predictors of change in plasma XOR activity after adjustment of age, sex and changes in each variable with a significant correlation without multicollinearity. In conclusion, annual change in plasma XOR activity is independently associated with changes in liver enzymes and body weight in a general population. Improvement of liver function and reduction of body weight would decrease plasma XOR activity and its related oxidative stress as a therapeutic strategy.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Xanthine Dehydrogenase
Endocrinology, Diabetes and Metabolism
Population
Aspartate transaminase
Blood Pressure
030209 endocrinology & metabolism
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Insulin resistance
Japan
Internal medicine
medicine
Humans
Aspartate Aminotransferases
Longitudinal Studies
Hyperuricemia
Xanthine oxidase
education
Aged
Aged, 80 and over
education.field_of_study
biology
Body Weight
Alanine Transaminase
gamma-Glutamyltransferase
Middle Aged
medicine.disease
Liver
chemistry
Alanine transaminase
030220 oncology & carcinogenesis
biology.protein
Uric acid
Female
sense organs
Liver function
Biomarkers
Subjects
Details
- ISSN :
- 13484540 and 09188959
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Endocrine Journal
- Accession number :
- edsair.doi.dedup.....dc90d13faf5afb0850f2336e9073de44