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Neonatal Hair Analysis for Benzoylecgonine: A Sensitive and Semiquantitative Biological Marker for Chronic Gestational Cocaine Exposure
- Source :
- Neonatology. 81:29-37
- Publication Year :
- 2002
- Publisher :
- S. Karger AG, 2002.
-
Abstract
- Hair analysis for the major metabolite of cocaine, benzoylecgonine (BZE) was performed in a cohort of 251 predominantly African-American newborns utilizing a modified radioimmunoassay (RIA) (Abuscreen Roche Laboratories, Nutley, N.J., USA). Maternal drug intake was confirmed by positive urine drug screen for cocaine metabolites at the time of delivery. The BZE concentrations reported here are the composites of both the parent compound cocaine (hydrolyzed to BZE) and the native BZE metabolized by the patient and deposited in the hair follicle. Hair analysis as an indicator for gestational cocaine exposure had a sensitivity of 88%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 85%. The range of BZE was 99–23,300 ng/g of hair, with 79% having hair BZE levels
- Subjects :
- Adult
medicine.medical_specialty
Metabolite
Gestational Age
Sensitivity and Specificity
chemistry.chemical_compound
Cocaine
Pregnancy
Internal medicine
Ethnicity
medicine
Birth Weight
Humans
Maternal-Fetal Exchange
Neonatal hair
biology
business.industry
Hair analysis
Infant, Newborn
Gestational age
Radioimmunoassay
biology.organism_classification
Endocrinology
chemistry
Pediatrics, Perinatology and Child Health
Benzoylecgonine
Gestation
Female
business
Cabello
Biomarkers
Hair
Developmental Biology
Subjects
Details
- ISSN :
- 16617819 and 16617800
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Neonatology
- Accession number :
- edsair.doi.dedup.....dc8d1dd35c379a04dae626a009546834