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Phosphoketolase pathway engineering for carbon-efficient biocatalysis
- Source :
- Current opinion in biotechnology. 36
- Publication Year :
- 2015
-
Abstract
- Recent advances in metabolic engineering have facilitated the development of microbial biocatalysts capable of producing an array of bio-products, ranging from fuels to drug molecules. These bio-products are commonly generated through an acetyl-CoA intermediate, which serves as a key precursor in the biological conversion of carbon substrates. Conventional biocatalytic upgrading strategies proceeding through this route are limited by low carbon efficiencies, in large part due to carbon losses associated with pyruvate decarboxylation to acetyl-CoA. Bypass of pyruvate decarboxylation offers a means to dramatically enhance carbon yields and, in turn, bioprocess economics. Herein, we discuss recent advances and prospects for employing the phosphoketolase pathway for direct biosynthesis of acetyl-CoA from carbon substrates, and phosphoketolase-based metabolic engineering strategies for carbon efficient biocatalysis.
- Subjects :
- Pyruvate decarboxylation
Aldehyde lyases
Biomedical Engineering
Phosphoketolase
Carbohydrates
chemistry.chemical_element
Bioengineering
Combinatorial chemistry
Carbon
Metabolic engineering
chemistry
Metabolic Engineering
Biocatalysis
Organic chemistry
Carbohydrate Metabolism
Bioprocess
Biotechnology
Pathway engineering
Aldehyde-Lyases
Subjects
Details
- ISSN :
- 18790429
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Current opinion in biotechnology
- Accession number :
- edsair.doi.dedup.....dc79f340dce110b4be77c5daea35ce24