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Sepsis take-out: Inhibiting bacterial deliveries
- Source :
- Immunity. 54:399-401
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Summary Sepsis remains a deadly disease with limited treatment options. In this issue of Immunity, Tang et al. propose that heparin provides protection during gram-negative sepsis by dampening harmful CASP11-dependent signaling through inhibition of HMGB1- and heparanase-mediated cytosolic delivery of LPS.
- Subjects :
- Lipopolysaccharides
0301 basic medicine
Immunology
chemical and pharmacologic phenomena
Disease
Bioinformatics
HMGB1
Sepsis
03 medical and health sciences
0302 clinical medicine
Immunity
medicine
Humans
Immunology and Allergy
HMGB1 Protein
biology
Cytosolic delivery
Treatment options
Heparin
medicine.disease
030104 developmental biology
Infectious Diseases
030220 oncology & carcinogenesis
biology.protein
Gram-Negative Bacterial Infections
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....dc6448426a9fafc818a717e6f031197a