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Emerging modes-of-action in drug discovery
- Source :
- Medchemcomm
- Publication Year :
- 2019
-
Abstract
- An increasing focus on complex biology to cure diseases rather than merely treat symptoms has transformed how drug discovery can be approached. Instead of activating or blocking protein function, a growing repertoire of drug modalities can be leveraged or engineered to hijack cellular processes, such as translational regulation or degradation mechanisms. Drug hunters can therefore access a wider arsenal of modes-of-action to modulate biological processes and this review summarises these emerging strategies by highlighting the most representative examples of these approaches.
- Subjects :
- Pharmacology
Drug
Protein function
Modalities
010405 organic chemistry
Drug discovery
media_common.quotation_subject
Organic Chemistry
fungi
Chemie
Pharmaceutical Science
food and beverages
01 natural sciences
Biochemistry
0104 chemical sciences
Chemistry
010404 medicinal & biomolecular chemistry
Action (philosophy)
Drug Discovery
Molecular Medicine
Neuroscience
media_common
Subjects
Details
- Language :
- English
- ISSN :
- 20402503
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- MedChemComm
- Accession number :
- edsair.doi.dedup.....dc62365ad5fae184dda38d945d42f70d