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Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order
- Source :
- Comparative and Functional Genomics, Vol 2008 (2008), Comparative and Functional Genomics
- Publication Year :
- 2008
- Publisher :
- Hindawi Limited, 2008.
-
Abstract
- Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium that belongs to the order of Rickettsiales. Recently, we have reported thatO. tsutsugamushihas a unique genomic structure, consisting of highly repetitive sequences, and suggested that it may provide valuable insight into the evolution of intracellular bacteria. Here, we have used genomic information to construct the major metabolic pathways ofO. tsutsugamushiand performed a comparative analysis of the metabolic genes and pathways ofO. tsutsugamushiwith other members of the Rickettsiales order. WhileO. tsutsugamushihas the largest genome among the members of this order, mainly due to the presence of repeated sequences, its metabolic pathways have been highly streamlined. Overall, the metabolic pathways ofO. tsutsugamushiwere similar toRickettsiabut there were notable differences in several pathways including carbohydrate metabolism, the TCA cycle, and the synthesis of cell wall components as well as in the transport systems. Our results will provide a useful guide to the postgenomic analysis ofO. tsutsugamushiand lead to a better understanding of the virulence and physiology of this intracellular pathogen.
- Subjects :
- Genetics
Orientia tsutsugamushi
biology
lcsh:QH426-470
Intracellular parasite
Virulence
Scrub typhus
Review Article
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Genome
Microbiology
lcsh:Genetics
Rickettsia
lcsh:Biology (General)
medicine
lcsh:Q
Rickettsiales
lcsh:Science
Molecular Biology
Gene
lcsh:QH301-705.5
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 15326268 and 15316912
- Volume :
- 2008
- Database :
- OpenAIRE
- Journal :
- Comparative and Functional Genomics
- Accession number :
- edsair.doi.dedup.....dc50a127e1d1ccb95318009248ab7fc5