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Reproducibility of measurement of myometrial invasion in endometrial carcinoma
- Source :
- Repositorio Abierto de la UdL, Universitad de Lleida, Virchows Archiv, VIRCHOWS ARCHIV, Virchows Archiv, 470, 63-68, Recercat. Dipósit de la Recerca de Catalunya, instname, Virchows Archiv, 470, 1, pp. 63-68
- Publication Year :
- 2017
-
Abstract
- Contains fulltext : 174833.pdf (Publisher’s version ) (Open Access) Myometrial invasion (MI) as a percentage (%MI), categorized into /=50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasion (DOI) might be stronger predictors of prognosis. Although reproducibility is important in clinical practice for patient prognostication and treatment, reproducibility of these methods for the measurement of MI is largely unknown. One or two slides from 50 patients with FIGO stage I endometrioid endometrial carcinoma were viewed by seven gynecological pathologists, who were requested to measure %MI, TFD, and DOI. We categorized %MI as /=50 %, TFD as 1.75 mm (including no MI), 7 mm (including no MI), and 10 mm (including no MI) and DOI as /=4 mm. Light's kappa for multi-rater agreement was calculated. The %MI, TFD, and DOI could be measured in 88, 83, and 79 % of cases, respectively. Kappa was 0.75 for %MI, 0.77, 0.73, and 0.69 respectively for TFD with cutoffs of 1.75, 7, and 10 mm, and 0.59 for DOI. Pathologists reach substantial agreement when measuring %MI and TFD and moderate agreement when measuring DOI. The %MI can be measured in more cases than TFD and DOI. This supports the use of %MI in daily clinical practice, but future studies should compare %MI and TFD more extensively, including inter-observer variability.
- Subjects :
- Pathology
Future studies
0302 clinical medicine
PROGNOSTIC-SIGNIFICANCE
Medicine and Health Sciences
Medicine
SUPERIOR
Observer Variation
Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]
030219 obstetrics & reproductive medicine
General Medicine
Prognosis
CANCER
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
3. Good health
Clinical Practice
GRADE
Depth of invasion
030220 oncology & carcinogenesis
Original Article
Female
Observer variation
UTERINE SEROSA
Tumor-free distance
medicine.medical_specialty
MYOINVASION
Endometrial carcinoma
Pathology and Forensic Medicine
03 medical and health sciences
Carcinoma
Humans
Neoplasm Invasiveness
Molecular Biology
Neoplasm Staging
Myometrial invasion
Reproducibility
business.industry
Reproducibility of Results
Inter-observer variability
ADENOCARCINOMA
Cell Biology
medicine.disease
Endometrial Neoplasms
DEPTH
INTEROBSERVER AGREEMENT
Neoplasm Recurrence, Local
business
Nuclear medicine
Kappa
Subjects
Details
- ISSN :
- 09456317 and 14322307
- Volume :
- 470
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi.dedup.....dc459d74bfd9e9a02774486103825020