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Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China
- Source :
- Journal of Medical Internet Research
- Publication Year :
- 2021
- Publisher :
- JMIR Publications Inc., 2021.
-
Abstract
- Background Routine HIV testing accompanied with pre-exposure prophylaxis (PrEP) requires innovative support in a real-world setting. Objective This study aimed to determine the usage of HIV self-testing (HIVST) kits and their secondary distribution to partners among men who have sex with men (MSM) in China, who use PrEP, in an observational study between 2018 and 2019. Methods In 4 major cities in China, we prospectively followed-up MSM from the China Real-world oral PrEP demonstration study, which provides daily or on-demand PrEP for 12 months, to assess the usage and secondary distribution of HIVST on quarterly follow-ups. Half of the PrEP users were randomized to receive 2 HIVSTs per month in addition to quarterly facility-based HIV testing. We evaluated the feasibility of providing HIVST to PrEP users. Results We recruited 939 MSM and randomized 471 to receive HIVST, among whom 235 (49.9%) were daily and 236 (50.1%) were on-demand PrEP users. At baseline, the median age was 29 years, 390 (82.0%) men had at least college-level education, and 119 (25.3%) had never undergone facility-based HIV testing before. Three months after PrEP initiation, 341 (74.5%) men had used the HIVST provided to them and found it very easy to use. Among them, 180 of 341 (52.8%) men had distributed the HIVST kits it to other MSM, and 132 (51.6%) among the 256 men who returned HIVST results reported that used it with their sexual partners at the onset of intercourse. Participants on daily PrEP were more likely to use HIVST (adjusted hazard ratio=1.3, 95% CI 1.0-1.6) and distribute HIVST kits (adjusted hazard ratio=1.3, 95% CI 1.1-1.7) than those using on-demand PrEP. Conclusions MSM who used PrEP had a high rate of usage and secondary distribution of HIVST kits, especially among those on daily PrEP, which suggested high feasibility and necessity for HIVST after PrEP initiation. Assuming that fourth-generation HIVST kits are available, HIVST may be able to replace facility-based HIV testing to a certain extent. Trial Registration Chinese Clinical Trial Registry ChiCTR1800020374; https://www.chictr.org.cn/showprojen.aspx?proj=32481 International Registered Report Identifier (IRRID) RR2-10.1136/bmjopen-2019-036231
- Subjects :
- Adult
Male
secondary distribution
China
medicine.medical_specialty
HIV self-testing
Human immunodeficiency virus (HIV)
men who have sex with men
HIV Infections
Health Informatics
medicine.disease_cause
Men who have sex with men
Cohort Studies
Sexual and Gender Minorities
Pre-exposure prophylaxis
Internet based
medicine
Humans
Prospective Studies
Homosexuality, Male
Prospective cohort study
Internet
Original Paper
business.industry
Hazard ratio
usage
Clinical trial
Self-Testing
Family medicine
Pre-Exposure Prophylaxis
Observational study
business
Subjects
Details
- ISSN :
- 14388871 and 14394456
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Internet Research
- Accession number :
- edsair.doi.dedup.....dc44e1546f2541214bb8ae577e6706ef