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The genomics of heart failure: design and rationale of the HERMES consortium
- Source :
- ESC Heart Failure, ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩, 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure . https://doi.org/10.1002/ehf2.13517, ESC Heart Failure. WILEY PERIODICALS, INC, ESC Heart Failure, 8(6), 5531-5541. WILEY PERIODICALS, INC, ESC heart failure, 8(6), 5531-5541. The Heart Failure Association of the European Society of Cardiology, ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩, Regeneron Genetics Center 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517, Esc heart failure, 8(6). John Wiley & Sons Inc., Lumbers, R T, Shah, S, Lin, H, Czuba, T, Henry, A, Swerdlow, D I, Mälarstig, A, Andersson, C, Verweij, N, Holmes, M V, Ärnlöv, J, Svensson, P, Hemingway, H, Sallah, N, Almgren, P, Aragam, K G, Asselin, G, Backman, J D, Biggs, M L, Bloom, H L, Boersma, E, Brandimarto, J, Brown, M R, Brunner-La Rocca, H P, Carey, D J, Chaffin, M D, Chasman, D I, Chazara, O, Chen, X, Chen, X, Chung, J H, Chutkow, W, Cleland, J G F, Cook, J P, de Denus, S, Dehghan, A, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Engström, G, Esko, T, Fatemifar, G, Felix, S B, Finan, C, Ford, I, Fougerousse, F, Fouodjio, R, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gui, H, Gutmann, R, Haggerty, C M, van der Harst, P, Hedman, Å K, Helgadottir, A, Hillege, H, Hyde, C L, Jacob, J, Jukema, J W, Kamanu, F, Kardys, I, Kavousi, M, Khaw, K T, Kleber, M E, Køber, L, Koekemoer, A, Kraus, B, Kuchenbaecker, K, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Mann, D, Margulies, K B, Marston, N A, März, W, McMurray, J J V, Melander, O, Melloni, G, Mordi, I R, Morley, M P, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Newton-Cheh, C, Niessner, A, Niiranen, T, Nowak, C, O'Donoghue, M L, Owens, A T, Palmer, C N A, Paré, G, Perola, M, Perreault, L P L, Portilla-Fernandez, E, Psaty, B M, Rice, K M, Ridker, P M, Romaine, S P R, Roselli, C, Rotter, J I, Ruff, C T, Sabatine, M S, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stefansson, K, Stender, S, Stott, D J, Sveinbjörnsson, G, Tammesoo, M L, Tardif, J C, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tuckwell, D, Tyl, B, Uitterlinden, A G, Vaura, F, Veluchamy, A, Visscher, P M, Völker, U, Voors, A A, Wang, X, Wareham, N J, Weeke, P E, Weiss, R, White, H D, Wiggins, K L, Xing, H, Yang, J, Yang, Y, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, F, Regeneron Genetics Center, Wilk, J B, Holm, H, Sattar, N, Lubitz, S A, Lanfear, D E, Shah, S, Dunn, M E, Wells, Q S, Asselbergs, F W, Hingorani, A D, Dubé, M P, Samani, N J, Lang, C C, Cappola, T P, Ellinor, P T, Vasan, R S & Smith, J G 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC Heart Failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517, ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model.Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
- Subjects :
- Male
Study Designs
Cardiomyopathy
Disease
030204 cardiovascular system & hematology
0302 clinical medicine
AFRICAN ANCESTRY
Epidemiology
80 and over
WIDE ASSOCIATION
EPIDEMIOLOGY
Cardiac and Cardiovascular Systems
AGING RESEARCH
RISK
Aged, 80 and over
0303 health sciences
Kardiologi
Genomics
Middle Aged
Prognosis
3. Good health
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Heart failure
CLASSIFICATION
Heart Failure/genetics
03 medical and health sciences
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
Genetic model
medicine
Genetics
Diseases of the circulatory (Cardiovascular) system
Humans
Allele frequency
Genotyping
METAANALYSIS
030304 developmental biology
Aged
Association studies
Study Design
business.industry
Odds ratio
ADULTS
COHORTS
medicine.disease
RC666-701
REPLICATION
business
Biomarkers
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20555822
- Database :
- OpenAIRE
- Journal :
- ESC Heart Failure, ESC Heart Failure, Wiley, 2021, ⟨10.1002/ehf2.13517⟩, 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure . https://doi.org/10.1002/ehf2.13517, ESC Heart Failure. WILEY PERIODICALS, INC, ESC Heart Failure, 8(6), 5531-5541. WILEY PERIODICALS, INC, ESC heart failure, 8(6), 5531-5541. The Heart Failure Association of the European Society of Cardiology, ESC Heart Failure, 2021, ⟨10.1002/ehf2.13517⟩, Regeneron Genetics Center 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC heart failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517, Esc heart failure, 8(6). John Wiley & Sons Inc., Lumbers, R T, Shah, S, Lin, H, Czuba, T, Henry, A, Swerdlow, D I, Mälarstig, A, Andersson, C, Verweij, N, Holmes, M V, Ärnlöv, J, Svensson, P, Hemingway, H, Sallah, N, Almgren, P, Aragam, K G, Asselin, G, Backman, J D, Biggs, M L, Bloom, H L, Boersma, E, Brandimarto, J, Brown, M R, Brunner-La Rocca, H P, Carey, D J, Chaffin, M D, Chasman, D I, Chazara, O, Chen, X, Chen, X, Chung, J H, Chutkow, W, Cleland, J G F, Cook, J P, de Denus, S, Dehghan, A, Delgado, G E, Denaxas, S, Doney, A S, Dörr, M, Dudley, S C, Engström, G, Esko, T, Fatemifar, G, Felix, S B, Finan, C, Ford, I, Fougerousse, F, Fouodjio, R, Ghanbari, M, Ghasemi, S, Giedraitis, V, Giulianini, F, Gottdiener, J S, Gross, S, Guðbjartsson, D F, Gui, H, Gutmann, R, Haggerty, C M, van der Harst, P, Hedman, Å K, Helgadottir, A, Hillege, H, Hyde, C L, Jacob, J, Jukema, J W, Kamanu, F, Kardys, I, Kavousi, M, Khaw, K T, Kleber, M E, Køber, L, Koekemoer, A, Kraus, B, Kuchenbaecker, K, Langenberg, C, Lind, L, Lindgren, C M, London, B, Lotta, L A, Lovering, R C, Luan, J, Magnusson, P, Mahajan, A, Mann, D, Margulies, K B, Marston, N A, März, W, McMurray, J J V, Melander, O, Melloni, G, Mordi, I R, Morley, M P, Morris, A D, Morris, A P, Morrison, A C, Nagle, M W, Nelson, C P, Newton-Cheh, C, Niessner, A, Niiranen, T, Nowak, C, O'Donoghue, M L, Owens, A T, Palmer, C N A, Paré, G, Perola, M, Perreault, L P L, Portilla-Fernandez, E, Psaty, B M, Rice, K M, Ridker, P M, Romaine, S P R, Roselli, C, Rotter, J I, Ruff, C T, Sabatine, M S, Salo, P, Salomaa, V, van Setten, J, Shalaby, A A, Smelser, D T, Smith, N L, Stefansson, K, Stender, S, Stott, D J, Sveinbjörnsson, G, Tammesoo, M L, Tardif, J C, Taylor, K D, Teder-Laving, M, Teumer, A, Thorgeirsson, G, Thorsteinsdottir, U, Torp-Pedersen, C, Trompet, S, Tuckwell, D, Tyl, B, Uitterlinden, A G, Vaura, F, Veluchamy, A, Visscher, P M, Völker, U, Voors, A A, Wang, X, Wareham, N J, Weeke, P E, Weiss, R, White, H D, Wiggins, K L, Xing, H, Yang, J, Yang, Y, Yerges-Armstrong, L M, Yu, B, Zannad, F, Zhao, F, Regeneron Genetics Center, Wilk, J B, Holm, H, Sattar, N, Lubitz, S A, Lanfear, D E, Shah, S, Dunn, M E, Wells, Q S, Asselbergs, F W, Hingorani, A D, Dubé, M P, Samani, N J, Lang, C C, Cappola, T P, Ellinor, P T, Vasan, R S & Smith, J G 2021, ' The genomics of heart failure : design and rationale of the HERMES consortium ', ESC Heart Failure, vol. 8, no. 6, pp. 5531-5541 . https://doi.org/10.1002/ehf2.13517, ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
- Accession number :
- edsair.doi.dedup.....dc41b40a62755853d7042fbc1dfd58a0