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Inverse comorbidity in multiple sclerosis: Findings in a complete nationwide cohort
- Source :
- Thormann, A, Koch-Henriksen, N, Laursen, B, Sørensen, P S & Magyari, M 2016, ' Inverse comorbidity in multiple sclerosis : Findings in a complete nationwide cohort ', Multiple Sclerosis and Related Disorders, vol. 10, pp. 181-186 . https://doi.org/10.1016/j.msard.2016.10.008
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- BACKGROUND: Inverse comorbidity is disease occurring at lower rates than expected among persons with a given index disease. The objective was to identify inverse comorbidity in MS.METHODS: We performed a combined case-control and cohort study in a total nationwide cohort of cases with clinical onset of MS 1980-2005. We randomly matched each MS-case with five population controls. Comorbidity data were obtained from multiple, independent nationwide registries. Cases and controls were followed from January 1977 to the index date, and from the index date through December 2012. We controlled for false discovery rate and investigated each of eight pre-specified comorbidity categories: psychiatric, cerebrovascular, cardiovascular, lung, and autoimmune comorbidities, diabetes, cancer, and Parkinson's disease.RESULTS: A total of 8947 MS-cases and 44,735 controls were eligible for inclusion. We found no inverse associations with MS before the index date. After the index date, we found a decreased occurrence of chronic lung disease (asthma and chronic obstructive pulmonary disease) (HR 0.80 (95% CI 0.75-0.86, pCONCLUSION: This study showed a decreased risk of cancers and pulmonary diseases after onset of MS. Identification of inverse comorbidity and of its underlying mechanisms may provide important new entry points into the understanding of MS.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Denmark
Population
Comorbidity
Disease
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Epidemiology
medicine
Humans
Registries
030212 general & internal medicine
education
Aged
Proportional Hazards Models
Asthma
education.field_of_study
business.industry
General Medicine
Middle Aged
medicine.disease
Neurology
Case-Control Studies
Cohort
Physical therapy
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 22110348 and 19802005
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis and Related Disorders
- Accession number :
- edsair.doi.dedup.....dc3fc7361b63308b721371415068dec4